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    plekha1a pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1a [ Danio rerio (zebrafish) ]

    Gene ID: 406745, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plekha1aprovided by ZNC
    Official Full Name
    pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2780
    See related
    Ensembl:ENSDARG00000030064 AllianceGenome:ZFIN:ZDB-GENE-040426-2780
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc34a05; fc57h12; plekha1; zgc:55676; wu:fc34a05; wu:fc57h12
    Summary
    Predicted to enable phosphatidylinositol-3,4-bisphosphate binding activity and phospholipid binding activity. Predicted to be involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PLEKHA1 (pleckstrin homology domain containing A1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See plekha1a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (21887853..21913328)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (21867987..21893492)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene CUB and zona pellucida-like domain-containing protein 1 Neighboring gene CUB and zona pellucida-like domain-containing protein 1 Neighboring gene CUB and zona pellucida-like domains 1, tandem duplicate 1 Neighboring gene HtrA serine peptidase 1a Neighboring gene cysteine-rich protein 3 Neighboring gene solute carrier family 22 member 7b, tandem duplicate 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family A member 1a
    Names
    pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213436.1 → NP_998601.1  pleckstrin homology domain-containing family A member 1a

      See identical proteins and their annotated locations for NP_998601.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044452
      UniProtKB/TrEMBL
      Q7ZYX2
      Related
      ENSDARP00000133411.2, ENSDART00000165192.2
      Conserved Domains (3) summary
      cd13270
      Location:1 → 118
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:184 → 297
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:191 → 287
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      21887853..21913328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158692.4 → XP_005158749.1  pleckstrin homology domain-containing family A member 1a isoform X2

      UniProtKB/TrEMBL
      A0A8M2B5K1
      Conserved Domains (3) summary
      cd13270
      Location:1 → 118
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:184 → 297
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:191 → 287
      PH; PH domain

    2. XM_017351618.3 → XP_017207107.1  pleckstrin homology domain-containing family A member 1a isoform X1

      UniProtKB/TrEMBL
      A0A8M6YVK6, E9QH37
      Related
      ENSDARP00000122375.1, ENSDART00000131929.3

    3. XM_009293024.4 → XP_009291299.1  pleckstrin homology domain-containing family A member 1a isoform X3

      See identical proteins and their annotated locations for XP_009291299.1

      UniProtKB/TrEMBL
      A0A8M3AU84
      Conserved Domains (3) summary
      cd13270
      Location:1 → 118
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:184 → 297
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:191 → 287
      PH; PH domain

    4. XM_009293023.4 → XP_009291298.1  pleckstrin homology domain-containing family A member 1a isoform X3

      See identical proteins and their annotated locations for XP_009291298.1

      UniProtKB/TrEMBL
      A0A8M3AU84
      Conserved Domains (3) summary
      cd13270
      Location:1 → 118
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:184 → 297
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:191 → 287
      PH; PH domain

    RNA

    1. XR_002455898.2 RNA Sequence

    2. XR_222431.5 RNA Sequence

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394986.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      135393..160862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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