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    rrp8 ribosomal RNA processing 8 [ Danio rerio (zebrafish) ]

    Gene ID: 797198, updated on 4-Jan-2025

    Summary

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    Official Symbol
    rrp8provided by ZNC
    Official Full Name
    ribosomal RNA processing 8provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8898
    See related
    Ensembl:ENSDARG00000071652 AllianceGenome:ZFIN:ZDB-GENE-030131-8898
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fk33d07; wu:fk33d07; si:ch211-149e23.3; si:ch211-152b13.1
    Summary
    Predicted to enable methylated histone binding activity. Predicted to be involved in cellular response to glucose starvation; rDNA heterochromatin formation; and regulation of transcription by glucose. Predicted to act upstream of or within methylation. Predicted to be located in rDNA heterochromatin. Predicted to be part of chromatin silencing complex. Predicted to be active in nucleolus. Orthologous to human RRP8 (ribosomal RNA processing 8). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See rrp8 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (15221264..15230260, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (15284792..15294274, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene si:ch211-149e23.4 Neighboring gene transfer RNA lysine (anticodon CUU) Neighboring gene transfer RNA lysine (anticodon CUU) Neighboring gene mediator complex subunit 29 Neighboring gene C2 domain containing 3 centriole elongation regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RES complex is associated with intron definition and required for zebrafish early embryogenesis. Fernandez JP, et al. PLoS Genet, 2018 Jul. PMID 29969449, Free PMC Article
    2. Melanoma genome evolution across species. Kansler ER, et al. BMC Genomics, 2017 Feb 7. PMID 28173755, Free PMC Article
    3. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rDNA heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by glucose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin silencing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in rDNA heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal RNA-processing protein 8
    Names
    ribosomal RNA processing 8, methyltransferase, homolog
    XP_001334686.1
    XP_021328585.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      15221264..15230260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001334650.8 → XP_001334686.1  ribosomal RNA-processing protein 8

      UniProtKB/TrEMBL
      A0A8M1PYX1, F1R692
      Related
      ENSDARP00000128801.1, ENSDART00000155400.2
      Conserved Domains (2) summary
      pfam15299
      Location:153 → 220
      ALS2CR8; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8
      cl17173
      Location:321 → 533
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394939.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      82083..91175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472910.2 → XP_021328585.1  ribosomal RNA-processing protein 8

      UniProtKB/TrEMBL
      B0R0L1
      Conserved Domains (3) summary
      pfam15299
      Location:153 → 220
      ALS2CR8; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8
      cl17173
      Location:321 → 533
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      cl25574
      Location:85 → 300
      TOP2c; TopoisomeraseII
    Nucleotide Protein Strain
    Heading Accession and Version

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