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    crkl v-crk avian sarcoma virus CT10 oncogene homolog-like [ Danio rerio (zebrafish) ]

    Gene ID: 556443, updated on 9-Dec-2024

    Summary

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    Official Symbol
    crklprovided by ZNC
    Official Full Name
    v-crk avian sarcoma virus CT10 oncogene homolog-likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2951
    See related
    Ensembl:ENSDARG00000028699 AllianceGenome:ZFIN:ZDB-GENE-040426-2951
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63469; wu:fa55g05; wu:fj60e01
    Summary
    Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Acts upstream of or within myoblast fusion; pronephros morphogenesis; and retina layer formation. Predicted to be active in cytoplasm. Is expressed in nervous system; otic vesicle; and pronephros. Human ortholog(s) of this gene implicated in chronic myeloid leukemia. Orthologous to human CRKL (CRK like proto-oncogene, adaptor protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See crkl in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (18950575..18958079)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (18913939..18921443)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene sphingomyelin phosphodiesterase 4 Neighboring gene si:ch211-222n4.2 Neighboring gene mediator complex subunit 15 Neighboring gene serine/threonine-protein kinase pim-1 Neighboring gene MAGUK p55 subfamily member 4-like Neighboring gene uncharacterized LOC137488799

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Crk adaptor proteins are necessary for the development of the zebrafish retina. Stergas HR, et al. Dev Dyn, 2022 Feb. PMID 34268820, Free PMC Article
    2. Crk1/2 and CrkL play critical roles in maintaining podocyte morphology and function. Du J, et al. Exp Cell Res, 2020 Sep 1. PMID 32535035
    3. A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion. Moore CA, et al. Development, 2007 Sep. PMID 17670792
    4. Genetic Drivers of Kidney Defects in the DiGeorge Syndrome. Lopez-Rivera E, et al. N Engl J Med, 2017 Feb 23. PMID 28121514, Free PMC Article
    5. CRK and NCK adaptors may functionally overlap in zebrafish neurodevelopment, as indicated by common binding partners and overlapping expression patterns. Stergas HR, et al. FEBS Lett, 2024 Feb. PMID 38058169

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The adaptor proteins Crk and Crk-like (Crkl), with which Dock proteins are known to interact physically, are also required for myoblast fusion.
      Title: A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63469

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in enzyme-linked receptor protein signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pronephros development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pronephros morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retina layer formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    crk-like protein
    Names
    v-crk sarcoma virus CT10 oncogene homolog-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213538.1 → NP_998703.1  crk-like protein

      See identical proteins and their annotated locations for NP_998703.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056763
      UniProtKB/TrEMBL
      B7ZUZ0, Q6PH06
      Related
      ENSDARP00000037263.4, ENSDART00000036172.5
      Conserved Domains (3) summary
      cd09926
      Location:6 → 106
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:127 → 181
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
      cl17036
      Location:239 → 295
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      18950575..18958079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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