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    elk4 ETS transcription factor ELK4 [ Danio rerio (zebrafish) ]

    Gene ID: 30093, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elk4provided by ZNC
    Official Full Name
    ETS transcription factor ELK4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030716-1
    See related
    Ensembl:ENSDARG00000077092 AllianceGenome:ZFIN:ZDB-GENE-030716-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tcf; TCF-1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in endothelial cell. Orthologous to human ELK4 (ETS transcription factor ELK4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See elk4 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (38471470..38492269, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (38204265..38225064, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 18 Neighboring gene major facilitator superfamily domain containing 4Aa Neighboring gene si:ch211-117k10.3 Neighboring gene solute carrier family 45 member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a zebrafish TCF ETS-domain transcription factor. Brown LA, et al. Oncogene, 1999 Dec 23. PMID 10637509
    2. Genome-wide analysis of the zebrafish ETS family identifies three genes required for hemangioblast differentiation or angiogenesis. Liu F, et al. Circ Res, 2008 Nov 7. PMID 18832752
    3. ETS factors regulate Vegf-dependent arterial specification. Wythe JD, et al. Dev Cell, 2013 Jul 15. PMID 23830865, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC114016

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ETS domain-containing protein Elk-4
    Names
    ELK4, ETS-domain protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308956.1 → NP_001295885.1  ETS domain-containing protein Elk-4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL929286
      UniProtKB/TrEMBL
      A0A8M1P1J1, F1QFL0
      Related
      ENSDARP00000065612.6, ENSDART00000065613.7
      Conserved Domains (1) summary
      smart00413
      Location:17 → 89
      ETS; erythroblast transformation specific domain

    2. NM_130930.3 → NP_571005.2  ETS domain-containing protein Elk-4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL929286
      UniProtKB/TrEMBL
      A0A8N1TTL1, F1R0K1
      Related
      ENSDARP00000093624.3, ENSDART00000102850.5
      Conserved Domains (1) summary
      smart00413
      Location:17 → 89
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      38471470..38492269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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