U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    psme2 proteasome activator subunit 2 [ Danio rerio (zebrafish) ]

    Gene ID: 30647, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    psme2provided by ZNC
    Official Full Name
    proteasome activator subunit 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-991110-16
    See related
    Ensembl:ENSDARG00000033144 AllianceGenome:ZFIN:ZDB-GENE-991110-16
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    unp309
    Summary
    Predicted to enable endopeptidase activator activity. Predicted to be involved in positive regulation of endopeptidase activity; regulation of G1/S transition of mitotic cell cycle; and regulation of proteasomal protein catabolic process. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human PSME2 (proteasome activator subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See psme2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (13319439..13331961)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (13281136..13293658)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 9 Neighboring gene ER membrane protein complex subunit 9 Neighboring gene LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene drosha ribonuclease III Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 4b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification and linkage of the proteasome activator complex PA28 subunit genes in zebrafish. Murray BW, et al. Scand J Immunol, 2000 Jun. PMID 10849367
    2. Cloning and sequence analysis of cDNA for the proteasome activator PA28-beta subunit of flounder (Paralichthys olivaceus). Kim DH, et al. Mol Immunol, 2003 Dec. PMID 14597164
    3. Molecular cloning of proteasome activator PA28-beta subunit of large yellow croaker (Pseudosciana crocea) and its coordinated up-regulation with MHC class I alpha-chain and beta 2-microglobulin in poly I:C-treated fish. Liu G, et al. Mol Immunol, 2007 Feb. PMID 16901544
    4. Transcriptomic profiles of tumor-associated neutrophils reveal prominent roles in enhancing angiogenesis in liver tumorigenesis in zebrafish. Huo X, et al. Sci Rep, 2019 Feb 6. PMID 30728369, Free PMC Article
    5. Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation. Ung CY, et al. BMC Genomics, 2010 Mar 30. PMID 20353558, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables endopeptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of proteasomal protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome activator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    proteasome activator complex subunit 2
    Names
    pA28-b
    proteasome (prosome, macropain) activator subunit 2 (PA28 beta)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131374.1 → NP_571449.1  proteasome activator complex subunit 2

      See identical proteins and their annotated locations for NP_571449.1

      Status: PROVISIONAL

      Source sequence(s)
      AF195051
      UniProtKB/TrEMBL
      Q6NXB3, Q9PUC4
      Related
      ENSDARP00000049166.3, ENSDART00000049167.4
      Conserved Domains (2) summary
      pfam02251
      Location:13 → 65
      PA28_alpha; Proteasome activator pa28 alpha subunit
      pfam02252
      Location:101 → 242
      PA28_beta; Proteasome activator pa28 beta subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      13319439..13331961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.