foxh1 forkhead box H1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: foxh1provided by ZNC
Official Full Name: forkhead box H1provided by ZNC
Primary source: ZFIN:ZDB-GENE-000616-15
See related: Ensembl:ENSDARG00000055630 AllianceGenome:ZFIN:ZDB-GENE-000616-15
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: SUR; fast; fast1; fe26b06; schmalspur; wu:fe26b06; wu:fi30c08; wu:fi32b01
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and regionalization. Located in chromatin. Is expressed in several structures, including nervous system; oocyte; pericardial region; presumptive diencephalon; and ventral mesoderm. Orthologous to human FOXH1 (forkhead box H1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (13724549..13730523, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (13685805..13692329, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we identify a previously unappreciated role for the Nodal-transcription factor FoxH1 in mediating cell responsiveness to Bmp further linking the control of these two pathways in the heart
Title: Integration of nodal and BMP signals in the heart requires FoxH1 to create left-right differences in cell migration rates that direct cardiac asymmetry.
Axial mesoderm induction is differentially disrupted in FoxH1 mutants. FoxH1 mutants respond differently to Activin-like signaling.
Title: Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin.
to an essential role for maternal FoxH1 and downstream keratins during gastrulation that is epistatic to Nodal signaling
Title: An early requirement for maternal FoxH1 during zebrafish gastrulation.
flk1 is a direct target of FoxH1; FoxH1 is involved in vessel formation in zebrafish.
Title: FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish.
These results and the association of FoxH1 and Mixer/Bon with phosphorylated Smad2 support a role for these factors as components of the Nodal signaling pathway.
Title: Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm induction.

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General gene information

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Markers

fi32b01.x1 (e-PCR)
- UniSTS:204545

fi89f01.y1 (e-PCR)
- UniSTS:198177

fast1 (e-PCR)
- UniSTS:205635

fi30c08.x1 (e-PCR)
- UniSTS:197234

fi04b02.x1 (e-PCR)
- UniSTS:204417

fe26b06.x1 (e-PCR)
- UniSTS:196349

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables SMAD binding	IEA Inferred from Electronic Annotation more info
enables SMAD binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Spemann organizer formation at the embryonic shield	IMP Inferred from Mutant Phenotype more info
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axial mesoderm morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axial mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cytokine stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within embryonic heart tube left/right pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic heart tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm formation	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within floor plate development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within floor plate formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hypothalamus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens placode formation involved in camera-type eye formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesendoderm development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mesoderm formation	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within prechordal plate formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somite rostral/caudal axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within specification of animal organ position	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: forkhead box protein H1

Names: etID62177.12; fast-1; forkhead activin signal transducer 1; uncle freddy; unf

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131502.1 → NP_571577.1 forkhead box protein H1

See identical proteins and their annotated locations for NP_571577.1

Status: PROVISIONAL

Source sequence(s)

AF263000

UniProtKB/Swiss-Prot

Q9I8K6, Q9I9E1

UniProtKB/TrEMBL

B2GP52

Related

ENSDARP00000072485.4, ENSDART00000078021.7

Conserved Domains (1) summary

cd00059
Location:97 → 174

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

13724549..13730523 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068224645.1 → XP_068080746.1 forkhead box protein H1 isoform X1

UniProtKB/TrEMBL

A0A8M2B2E7, F1R6J3
XM_005156080.5 → XP_005156137.1 forkhead box protein H1 isoform X1

UniProtKB/TrEMBL

A0A8M2B2E7, F1R6J3

Related

ENSDARP00000127073.1, ENSDART00000152370.2

Conserved Domains (1) summary

cd00059
Location:97 → 174

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...