gpt glutamic--pyruvic transaminase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gptprovided by ZNC
Official Full Name: glutamic--pyruvic transaminaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050302-11
See related: Ensembl:ENSDARG00000019541 AllianceGenome:ZFIN:ZDB-GENE-050302-11
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gpt2; gpt2l; im:6791811; wu:fd46f01
Summary: Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity. Predicted to be involved in 2-oxoglutarate metabolic process and L-alanine metabolic process. Predicted to act upstream of or within biosynthetic process. Is expressed in liver. Orthologous to human GPT (glutamic--pyruvic transaminase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (3533121..3569958)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (3701942..3738964)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables L-alanine:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables L-alanine:2-oxoglutarate aminotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-alanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in L-alanine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: alanine aminotransferase 2-like

Names: ALT2; GPT 2; glutamate pyruvate transaminase 2; glutamic pyruvate transaminase (alanine aminotransferase) 2, like; glutamic--alanine transaminase 2; glutamic--pyruvic transaminase 2

NP_001136246.1

EC 2.6.1.2

XP_017213488.1

EC 2.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142774.1 → NP_001136246.1 alanine aminotransferase 2-like

Status: VALIDATED

Source sequence(s)

BX928742

UniProtKB/TrEMBL

A0A8M1NQS1

Related

ENSDARP00000121415.1, ENSDART00000132572.4

Conserved Domains (2) summary

cd00609
Location:120 → 472

AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

PTZ00377
Location:14 → 493

PTZ00377; alanine aminotransferase; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

3533121..3569958

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017357999.3 → XP_017213488.1 alanine aminotransferase 2-like isoform X1

UniProtKB/Swiss-Prot

A2BII0, Q6NYL5

Conserved Domains (2) summary

cd00609
Location:176 → 528

AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

PTZ00377
Location:70 → 549

PTZ00377; alanine aminotransferase; Provisional