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    arf6a ADP-ribosylation factor 6a [ Danio rerio (zebrafish) ]

    Gene ID: 336063, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arf6aprovided by ZNC
    Official Full Name
    ADP-ribosylation factor 6aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8007
    See related
    Ensembl:ENSDARG00000101626 AllianceGenome:ZFIN:ZDB-GENE-030131-8007
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    arf6; zgc:77665; wu:fj46d09
    Summary
    Predicted to enable GTP binding activity. Acts upstream of or within intrahepatic bile duct development; regulation of apoptotic process; and spinal cord development. Predicted to be located in Flemming body; cleavage furrow; and filopodium membrane. Predicted to be active in cytoplasmic vesicle; plasma membrane; and ruffle. Is expressed in intestinal bulb; liver; and pancreas. Orthologous to human ARF6 (ADP ribosylation factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See arf6a in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (54196542..54198130, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (54525723..54527311)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon GCU) Neighboring gene E3 ubiquitin-protein ligase pellino homolog 2 Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion a Neighboring gene PRP39 pre-mRNA processing factor 39 homolog (yeast)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Proteomics profiling of single organs from individual adult zebrafish. Abramsson A, et al. Zebrafish, 2010 Jun. PMID 20392139
    2. Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNS. Seo Y, et al. Int J Mol Sci, 2022 Nov 2. PMID 36362204, Free PMC Article
    3. Zebrafish fat-free, a novel Arf effector, regulates phospholipase D to mediate lipid and glucose metabolism. Liu HY, et al. Biochim Biophys Acta, 2010 Dec. PMID 20816853
    4. Arf6 and the 5'phosphatase of synaptojanin 1 regulate autophagy in cone photoreceptors. George AA, et al. Bioessays, 2016 Jul. PMID 27417116
    5. VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis. Watson S, et al. Cell Rep, 2023 Jan 31. PMID 36656711, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intrahepatic bile duct development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dendritic spine development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of oligodendrocyte apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within spinal cord development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in filopodium membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor 6a
    Names
    ADP-ribosylation factor 6
    NP_956287.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199993.1 → NP_956287.1  ADP-ribosylation factor 6a

      See identical proteins and their annotated locations for NP_956287.1

      Status: PROVISIONAL

      Source sequence(s)
      BC064293
      UniProtKB/TrEMBL
      A0A2R8QKX5, F6NLF6, Q6P2U5
      Related
      ENSDARP00000130480.1, ENSDART00000160409.2
      Conserved Domains (1) summary
      smart00177
      Location:1 → 175
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      54196542..54198130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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