tmprss4b transmembrane serine protease 4b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tmprss4bprovided by ZNC
Official Full Name: transmembrane serine protease 4bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5862
See related: Ensembl:ENSDARG00000012860 AllianceGenome:ZFIN:ZDB-GENE-030131-5862
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fi21e09; si:ch211-139a5.6
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Is expressed in integument and kidney. Orthologous to human TMPRSS4 (transmembrane serine protease 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (37903790..37912059)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (37303637..37311906)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protease serine 4b

Names: transmembrane protease, serine 4b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126377.1 → NP_001119849.1 transmembrane protease serine 4b

Status: PROVISIONAL

Source sequence(s)

BX465852

UniProtKB/TrEMBL

A0A0R4INC3, A0A8N1TS68

Related

ENSDARP00000137834.1, ENSDART00000162470.2

Conserved Domains (4) summary

smart00020
Location:201 → 424

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:202 → 427

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00530
Location:105 → 175

SRCR; Scavenger receptor cysteine-rich domain

pfam15494
Location:100 → 179

SRCR_2; Scavenger receptor cysteine-rich domain