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    pank1a pantothenate kinase 1a [ Danio rerio (zebrafish) ]

    Gene ID: 406789, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pank1aprovided by ZNC
    Official Full Name
    pantothenate kinase 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2846
    See related
    Ensembl:ENSDARG00000008192 AllianceGenome:ZFIN:ZDB-GENE-040426-2846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb79e08; zgc:63556; wu:fb79e08
    Summary
    Predicted to enable pantothenate kinase activity. Acts upstream of or within response to yeast. Predicted to be active in cytosol and nucleus. Is expressed in central nervous system and retina. Orthologous to human PANK1 (pantothenate kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pank1a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (23554900..23577017)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (23534859..23557620)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 7a Neighboring gene zgc:65997 Neighboring gene microRNA mir-107b Neighboring gene solute carrier family 16 member 12a Neighboring gene interferon-induced protein with tetratricopeptide repeats 16 Neighboring gene interferon-induced protein with tetratricopeptide repeats 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Bi-Allelic Mutations in Zebrafish pank2 Gene Lead to Testicular Atrophy and Perturbed Behavior without Signs of Neurodegeneration. Mignani L, et al. Int J Mol Sci, 2022 Oct 26. PMID 36361705, Free PMC Article
    2. Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease. Zizioli D, et al. Neurobiol Dis, 2016 Jan. PMID 26476142, Free PMC Article
    3. miR-103/107 regulates left-right asymmetry in zebrafish by modulating Kupffer's vesicle development and ciliogenesis. Heigwer J, et al. Biochem Biophys Res Commun, 2020 Jun 25. PMID 32334837
    4. Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. Wang YC, et al. BMC Syst Biol, 2013 Aug 16. PMID 23947337, Free PMC Article
    5. The zebrafish genes encoding the Polycomb repressive complex (PRC) 1. Le Faou P, et al. Gene, 2011 Apr 1. PMID 21195142

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pantothenate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to yeast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pantothenate kinase 1a
    NP_998645.2
    XP_005158562.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213480.2 → NP_998645.2  pantothenate kinase 1a

      Status: VALIDATED

      Source sequence(s)
      BX649437, CT954257
      UniProtKB/TrEMBL
      A0A8M1PFA2, F1QB40
      Related
      ENSDARP00000112870.1, ENSDART00000146787.3
      Conserved Domains (1) summary
      pfam03630
      Location:14 → 362
      Fumble; Fumble

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      23554900..23577017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158505.5 → XP_005158562.1  pantothenate kinase 1a isoform X1

      UniProtKB/TrEMBL
      A0A8M2B4X4
      Conserved Domains (1) summary
      pfam03630
      Location:80 → 428
      Fumble; Fumble

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394988.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      574767..593468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395331.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      140177..178683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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