nova2 NOVA alternative splicing regulator 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nova2provided by ZNC
Official Full Name: NOVA alternative splicing regulator 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-080211-1
See related: Ensembl:ENSDARG00000017673 AllianceGenome:ZFIN:ZDB-GENE-080211-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nova1a; sb:cb364; id:ibd1128
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in cytoplasm and nucleus. Is expressed in nervous system; neural plate; and posterior cardinal vein. Orthologous to several human genes including NOVA1 (NOVA alternative splicing regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (28685925..28766275)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (28753011..28833399)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Authors identify a mechanism whereby Nova2-regulated splicing constrains Erk signaling, thus limiting lymphatic progenitor cell specification.
Title: The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage.

Submit: New GeneRIF Correction

General gene information

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Markers

G40063 (e-PCR)
- UniSTS:57415

z8336 (e-PCR), detects polymorphism
- UniSTS:204959

fb50d02.x1 (e-PCR)
- UniSTS:190636

G40643 (e-PCR)
- UniSTS:72140

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA-binding protein Nova-2

Names: neuro-oncological ventral antigen 2; neurological oncogenic ventral antigen protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001309524.1 → NP_001296453.1 RNA-binding protein Nova-2

Status: VALIDATED

Source sequence(s)

BX088540, BX950186

UniProtKB/TrEMBL

A0A8M1P6N6, X1WBB9

Related

ENSDARP00000127510.1, ENSDART00000155815.3

Conserved Domains (2) summary

cd00105
Location:433 → 498

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:179 → 242

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

28685925..28766275

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001923455.8 → XP_001923490.1 RNA-binding protein Nova-2 isoform X1

UniProtKB/TrEMBL

A0A8M1QKW4, F1R4G7

Related

ENSDARP00000060243.3, ENSDART00000060244.4

Conserved Domains (2) summary

cd00105
Location:412 → 477

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:158 → 221

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...