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    tek TEK tyrosine kinase, endothelial [ Danio rerio (zebrafish) ]

    Gene ID: 30747, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tekprovided by ZNC
    Official Full Name
    TEK tyrosine kinase, endothelialprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-56
    See related
    Ensembl:ENSDARG00000028663 AllianceGenome:ZFIN:ZDB-GENE-990415-56
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tie2; tie-2
    Summary
    Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within angiogenesis and heart development. Predicted to be located in several cellular components, including cytoplasm; cytoskeleton; and focal adhesion. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in endothelial cell; vasculature; and vertical myoseptum. Human ortholog(s) of this gene implicated in arteriovenous malformation; multiple cutaneous and mucosal venous malformations; and renal Wilms' tumor. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tek in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (480080..496790)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (473662..497870)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495540 Neighboring gene intraflagellar transport 74 Neighboring gene uncharacterized LOC101883870 Neighboring gene uncharacterized LOC110439795

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Functional assessment of two variants of unknown significance in TEK by endothelium-specific expression in zebrafish embryos. Bell LM, et al. Hum Mol Genet, 2021 Dec 17. PMID 34254124
    2. Effects of simulated microgravity on the development of the swimbladder and buoyancy control in larval zebrafish (Danio rerio). Lindsey BW, et al. J Exp Zool A Ecol Genet Physiol, 2011 Jun 1. PMID 21394929
    3. Using Ultra-Performance Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry-Based Chemometrics for the Identification of Anti-angiogenic Biflavonoids from Edible Garcinia Species. Li P, et al. J Agric Food Chem, 2017 Sep 27. PMID 28926234
    4. Mirror movement-like defects in startle behavior of zebrafish dcc mutants are caused by aberrant midline guidance of identified descending hindbrain neurons. Jain RA, et al. J Neurosci, 2014 Feb 19. PMID 24553931, Free PMC Article
    5. Local cortical tension by myosin II guides 3D endothelial cell branching. Fischer RS, et al. Curr Biol, 2009 Feb 10. PMID 19185493, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tek (Tie2) is not required for cardiovascular development in zebrafish.
      Title: Tek (Tie2) is not required for cardiovascular development in zebrafish.
    2. observations demonstrate that Tie2 is an important regulator of tip cell behaviors
      Title: The zebrafish Tie2 signaling controls tip cell behaviors and acts synergistically with Vegf pathway in developmental angiogenesis.
    3. Tie-1 and Tie-2 are not required for early heart development, yet they have redundant roles for the maintenance of endocardial-myocardial connection in later stages.
      Title: Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endothelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heart development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    angiopoietin-1 receptor
    Names
    endothelium-specific receptor tyrosine kinase 2
    tyrosine kinase with Ig and EGF homology domains-2
    tyrosine-protein kinase receptor Tie-2
    NP_571536.1
    XP_009299388.1
    XP_021331678.1
    XP_021331680.1
    XP_068077196.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131461.1 → NP_571536.1  angiopoietin-1 receptor precursor

      See identical proteins and their annotated locations for NP_571536.1

      Status: PROVISIONAL

      Source sequence(s)
      AF053632
      UniProtKB/Swiss-Prot
      O73791
      Related
      ENSDARP00000055680.5, ENSDART00000055681.7
      Conserved Domains (7) summary
      cd05088
      Location:808 → 1110
      PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
      smart00060
      Location:632 → 716
      FN3; Fibronectin type 3 domain
      smart00221
      Location:816 → 1084
      STYKc; Protein kinase; unclassified specificity
      smart00410
      Location:354 → 439
      IG_like; Immunoglobulin like
      pfam00041
      Location:541 → 621
      fn3; Fibronectin type III domain
      pfam07974
      Location:224 → 255
      EGF_2; EGF-like domain
      pfam10430
      Location:25 → 121
      Ig_Tie2_1; Tie-2 Ig-like domain 1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      480080..496790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301113.4 → XP_009299388.1  angiopoietin-1 receptor isoform X1

      UniProtKB/TrEMBL
      A0A8M3ARU2
      Conserved Domains (7) summary
      cd05088
      Location:809 → 1111
      PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
      smart00060
      Location:633 → 717
      FN3; Fibronectin type 3 domain
      smart00221
      Location:817 → 1085
      STYKc; Protein kinase; unclassified specificity
      smart00410
      Location:354 → 439
      IG_like; Immunoglobulin like
      pfam00041
      Location:541 → 621
      fn3; Fibronectin type III domain
      pfam07974
      Location:224 → 255
      EGF_2; EGF-like domain
      pfam10430
      Location:25 → 121
      Ig_Tie2_1; Tie-2 Ig-like domain 1

    2. XM_068221095.1 → XP_068077196.1  angiopoietin-1 receptor isoform X2

    3. XM_021476003.2 → XP_021331678.1  angiopoietin-1 receptor isoform X3

      UniProtKB/TrEMBL
      A0A8M9PX37
      Conserved Domains (5) summary
      cd05088
      Location:689 → 991
      PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
      smart00060
      Location:513 → 597
      FN3; Fibronectin type 3 domain
      smart00410
      Location:234 → 319
      IG_like; Immunoglobulin like
      pfam07974
      Location:104 → 135
      EGF_2; EGF-like domain
      pfam00041
      Location:421 → 501
      fn3; Fibronectin type III domain

    4. XM_021476005.2 → XP_021331680.1  angiopoietin-1 receptor isoform X3

      UniProtKB/TrEMBL
      A0A8M9PX37
      Conserved Domains (5) summary
      cd05088
      Location:689 → 991
      PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
      smart00060
      Location:513 → 597
      FN3; Fibronectin type 3 domain
      smart00410
      Location:234 → 319
      IG_like; Immunoglobulin like
      pfam07974
      Location:104 → 135
      EGF_2; EGF-like domain
      pfam00041
      Location:421 → 501
      fn3; Fibronectin type III domain

    RNA

    1. XR_002458735.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O73791.1 GenPept UniProtKB/Swiss-Prot:O73791

    Gene LinkOut

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