U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    dlx3b distal-less homeobox 3b [ Danio rerio (zebrafish) ]

    Gene ID: 30585, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    dlx3bprovided by ZNC
    Official Full Name
    distal-less homeobox 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-280
    See related
    Ensembl:ENSDARG00000014626 AllianceGenome:ZFIN:ZDB-GENE-980526-280
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dlx3; dlx-3; zgc:91827; id:ibd3531; wu:fb83f11
    Summary
    Enables sequence-specific DNA binding activity. Acts upstream of or within several processes, including inner ear development; olfactory placode formation; and skeletal system development. Predicted to be located in nucleus. Is expressed in several structures, including ectoderm; neural crest; neural plate; neurogenic field; and pharyngeal arch. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 4 and trichodontoosseous syndrome. Orthologous to human DLX3 (distal-less homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See dlx3b in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (5708423..5711920)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (5673466..5676963)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene integrin, alpha 3b Neighboring gene microRNA mir-2186 Neighboring gene distal-less homeobox 4b Neighboring gene si:ch211-131k2.2 Neighboring gene K(lysine) acetyltransferase 7b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The zebrafish eya1 gene and its expression pattern during embryogenesis. Sahly I, et al. Dev Genes Evol, 1999 Jul. PMID 10370123
    2. An Assay for Systematically Quantifying the Vestibulo-Ocular Reflex to Assess Vestibular Function in Zebrafish Larvae. Sun P, et al. Front Cell Neurosci, 2018. PMID 30186115, Free PMC Article
    3. N-cadherin is required for the polarized cell behaviors that drive neurulation in the zebrafish. Hong E, et al. Development, 2006 Oct. PMID 16943271
    4. Exogenous retinoic acid induces a stage-specific, transient and progressive extension of Sonic hedgehog expression across the pectoral fin bud of zebrafish. Hoffman L, et al. Int J Dev Biol, 2002. PMID 12455633
    5. Close association of olfactory placode precursors and cranial neural crest cells does not predestine cell mixing. Harden MV, et al. Dev Dyn, 2012 Jul. PMID 22539261, Free PMC Article

    See all (293) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish.
      Title: Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish.
    2. Foxi1 and Dlx3b/4b regulate the neuronal and sensory lineages of the inner ear.
      Title: Zebrafish Foxi1 provides a neuronal ground state during inner ear induction preceding the Dlx3b/4b-regulated sensory lineage.
    3. the expression and function of hand2 and dlx3b/4b/5a genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches
      Title: hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches.
    4. These results provide insight into the mechanisms of preplacodal region (PPR) specification as well as the role of dlx3b/4b function in PPR and otic placode induction.
      Title: dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity.
    5. Dlx3b provide competence for cells to respond to Fgf and form an otic placode
      Title: Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b.
    6. Data suggest that the contribution of dlx3b and dlx4b to neural plate border formation is partially non-cell-autonomous acting via bone morphogenic protein activity.
      Title: dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurula.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within auditory receptor cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within camera-type eye development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cartilage development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chordate embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic skeletal system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within endocrine system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inner ear receptor cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lens fiber cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within olfactory placode development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within olfactory placode formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within otic placode formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within otic placode formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within otic vesicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within otic vesicle formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within otic vesicle formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within otic vesicle morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within otolith development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of bone development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tooth mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trigeminal nerve development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    homeobox protein Dlx3b
    Names
    distal-less homeobox gene 3b
    distal-less homeobox protein 3b

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131322.2 → NP_571397.2  homeobox protein Dlx3b

      See identical proteins and their annotated locations for NP_571397.2

      Status: PROVISIONAL

      Source sequence(s)
      BC078386
      UniProtKB/Swiss-Prot
      Q01702
      UniProtKB/TrEMBL
      B2GNK2, Q6DBS2
      Related
      ENSDARP00000022291.5, ENSDART00000017191.7
      Conserved Domains (2) summary
      pfam00046
      Location:128 → 181
      Homeobox; Homeobox domain
      pfam12413
      Location:28 → 104
      DLL_N; Homeobox protein distal-less-like N terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      5708423..5711920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01702.1 GenPept UniProtKB/Swiss-Prot:Q01702

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools