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    tspan4a tetraspanin 4a [ Danio rerio (zebrafish) ]

    Gene ID: 436620, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tspan4aprovided by ZNC
    Official Full Name
    tetraspanin 4aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-38
    See related
    Ensembl:ENSDARG00000089354 AllianceGenome:ZFIN:ZDB-GENE-040718-38
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92174
    Summary
    Acts upstream of or within with a positive effect on organelle assembly. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TSPAN4 (tetraspanin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tspan4a in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (50801307..50826393)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (50812090..50834369, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene zgc:158464 Neighboring gene transaldolase 1 Neighboring gene reelin-like Neighboring gene reelin-like Neighboring gene uncharacterized LOC137488356 Neighboring gene uncharacterized LOC137488355 Neighboring gene damage-specific DNA binding protein 1 Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Jiang D, et al. Nat Cell Biol, 2019 Aug. PMID 31371827
    2. Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets. Kalén M, et al. Chem Biol, 2009 Apr 24. PMID 19389629, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within_positive_effect organelle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of organelle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin-4a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002348.1 → NP_001002348.1  tetraspanin-4a

      See identical proteins and their annotated locations for NP_001002348.1

      Status: PROVISIONAL

      Source sequence(s)
      BC075913
      UniProtKB/TrEMBL
      A0A1L1QZT1, A0A8M1N0A2, A0A8M3AS88, Q6DHQ4
      Related
      ENSDARP00000143203.2, ENSDART00000174126.2
      Conserved Domains (2) summary
      cd03165
      Location:107 → 202
      NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:9 → 229
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      50801307..50826393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009293901.4 → XP_009292176.1  tetraspanin-4a isoform X1

      See identical proteins and their annotated locations for XP_009292176.1

      UniProtKB/TrEMBL
      A0A8M3B373, A0A8M9PQ52
      Conserved Domains (2) summary
      cd03165
      Location:189 → 284
      NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:91 → 311
      Tetraspannin; Tetraspanin family

    2. XM_009293903.4 → XP_009292178.1  tetraspanin-4a isoform X2

      UniProtKB/TrEMBL
      A0A8M3AV73, A0A8M9PQ52
      Conserved Domains (2) summary
      cl02781
      Location:190 → 250
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:91 → 277
      Tetraspannin; Tetraspanin family
    Nucleotide Protein Strain
    Heading Accession and Version

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