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    nsfl1c NSFL1 (p97) cofactor (p47) [ Danio rerio (zebrafish) ]

    Gene ID: 492805, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nsfl1cprovided by ZNC
    Official Full Name
    NSFL1 (p97) cofactor (p47)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-160
    See related
    Ensembl:ENSDARG00000087640 AllianceGenome:ZFIN:ZDB-GENE-041114-160
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zehn2383; wu:fc88f08; zgc:101636; hm:zehn2383
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including autophagosome assembly; nuclear membrane reassembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in Golgi stack and centrosome. Predicted to be active in cytosol and nucleus. Orthologous to human NSFL1C (NSFL1 cofactor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nsfl1c in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (18794832..18805565, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (18868489..18879222, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein b Neighboring gene epithelial membrane protein 3b (MAM blood group) Neighboring gene wu:fa11c10 Neighboring gene si:ch211-209j10.6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dynamics of Zebrafish Heart Regeneration Using an HPLC-ESI-MS/MS Approach. Ma D, et al. J Proteome Res, 2018 Mar 2. PMID 29369637
    2. Identification, characterization, and mapping of expressed sequence tags from an embryonic zebrafish heart cDNA library. Ton C, et al. Genome Res, 2000 Dec. PMID 11116087, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear membrane reassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NSFL1 cofactor p47

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007446.1 → NP_001007447.1  NSFL1 cofactor p47

      See identical proteins and their annotated locations for NP_001007447.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085395
      UniProtKB/TrEMBL
      Q5U3U1
      Related
      ENSDARP00000115283.1, ENSDART00000143065.3
      Conserved Domains (3) summary
      cd01770
      Location:294 → 372
      p47_UBX; p47-like ubiquitin domain
      smart00553
      Location:181 → 270
      SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47
      cd14348
      Location:5 → 44
      UBA_p47; UBA-like domain found in NSFL1 cofactor p47 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      18794832..18805565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009296732.2 → XP_009295007.1  NSFL1 cofactor p47 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AV68
      Conserved Domains (3) summary
      cd01770
      Location:293 → 371
      p47_UBX; p47-like ubiquitin domain
      smart00553
      Location:178 → 269
      SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47
      cd14348
      Location:5 → 44
      UBA_p47; UBA-like domain found in NSFL1 cofactor p47 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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