cyp19a1a cytochrome P450, family 19, subfamily A, polypeptide 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp19a1aprovided by ZNC
Official Full Name: cytochrome P450, family 19, subfamily A, polypeptide 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-43
See related: Ensembl:ENSDARG00000041348 AllianceGenome:ZFIN:ZDB-GENE-990415-43
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ar1; cyp19; cyp19a; cypXIX; CYP19a1; P450aromA; zgc:136541; etID309862.18
Summary: Predicted to enable aromatase activity. Acts upstream of with a positive effect on ovarian follicle development. Acts upstream of or within several processes, including primary sex determination, germ-line; regulation of estrogen biosynthetic process; and response to estradiol. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including endocrine system; eye; female organism; male organism; and reproductive system. Used to study disorder of sexual development. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (39620534..39636348, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (39639526..39655381, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

there is an interaction between cyp19a1a and dmrt1 in zebrafish gonadal differentiation; estrogens are dispensable in controlling early folliculogenesis
Title: Disruption of dmrt1 rescues the all-male phenotype of the cyp19a1a mutant in zebrafish - a novel insight into the roles of aromatase/estrogens in gonadal differentiation and early folliculogenesis.
cyp19a1a is expressed early during development, before the histological differentiation of the gonads, and the down-regulation of cyp19a1a expression is likely responsible for the testicular differentiation.
Title: Dynamic and differential expression of the gonadal aromatase during the process of sexual differentiation in a novel transgenic cyp19a1a-eGFP zebrafish line.
Knocking down the expression of gdf9 and cyp19a1a with vivo-morpholinos caused a male-skewed sex ratio.
Title: Expression analysis of growth differentiation factor 9 (Gdf9/gdf9), anti-müllerian hormone (Amh/amh) and aromatase (Cyp19a1a/cyp19a1a) during gonadal differentiation of the zebrafish, Danio rerio.
Mutant zebrafish lines lacking the ovarian aromatase gene (cyp19a1a) leads to all-male offspring, suggesting that aromatase plays a critical role in directing ovarian differentiation and development.
Title: Knockout of Zebrafish Ovarian Aromatase Gene (cyp19a1a) by TALEN and CRISPR/Cas9 Leads to All-male Offspring Due to Failed Ovarian Differentiation.
Dual functions of the cyp19a1a gene during sex differentiation: cyp19a1a is not only indispensable for female sex differentiation but also required for male sex differentiation.
Title: Targeted Disruption of Aromatase Reveals Dual Functions of cyp19a1a During Sex Differentiation in Zebrafish.
The whole-body androgen levels, follicle-stimulating hormone beta and luteinizing hormone beta protein levels in the pituitary, and transcript levels of genes known to be involved in spermatogenesis and steroidogenesis in the testes were significantly higher in the cyp19a1a mutant and aromatase double-mutant males than in the wild-type and cyp19a1b mutant male.
Title: New Insights Into the Role of Estrogens in Male Fertility Based on Findings in Aromatase-Deficient Zebrafish.
The results from the present study strongly suggest that DNA methylation is one of mechanisms that is involved in the regulation of cyp19a1a gene expression during folliculogenesis
Title: Dynamic methylation pattern of cyp19a1a core promoter during zebrafish ovarian folliculogenesis.
Data show that cytochrome P450 enzymes Cyp17-I, Cyp11c1, Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein Foxl2a were detected both in the testis and ovary.
Title: Localization of steroidogenic enzymes and Foxl2a in the gonads of mature zebrafish (Danio rerio).
Data indicate taht monocrotophos (MCP) exposure modulated gene expression of forkhead transcription factor gene L2 (foxl2), doublesex/mab-3 related transcription factor 1 (dmrt1), gonadal aromatase (cyp19a1a) and brain aromatase (cyp19a1b).
Title: Monocrotophos pesticide modulates the expression of sexual differentiation genes and causes phenotypic feminization in zebrafish (Danio rerio).
The differential expression of the aromatase genes, particularly CYP19A2 in the brain, suggests that the two aromatase genes play different roles in the reproductive behavior and/or physiology of bony fish.
Title: Localization and expression of aromatase mRNA in adult zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aromatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within female germ-line sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female gonad development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within female sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within female sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male germ-line sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of estrogen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to estradiol	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to estradiol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aromatase

Names: P-450AROM; cytochrome P-450AROM; cytochrome P450 19A1a; cytochrome P450, 19a; estrogen synthase; estrogen synthetase; ovarian aromatase

NP_571229.3

EC 1.14.14.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.