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    cenpk centromere protein K [ Danio rerio (zebrafish) ]

    Gene ID: 565144, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cenpkprovided by ZNC
    Official Full Name
    centromere protein Kprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090313-204
    See related
    Ensembl:ENSDARG00000039616 AllianceGenome:ZFIN:ZDB-GENE-090313-204
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-179o14.3
    Summary
    Predicted to be involved in mitotic sister chromatid segregation. Predicted to act upstream of or within kinetochore assembly. Predicted to be located in chromosome, centromeric region and nucleus. Orthologous to human CENPK (centromere protein K). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cenpk in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (31508735..31516148, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (30776171..30783753, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103908890 Neighboring gene regulating synaptic membrane exocytosis 1b Neighboring gene uncharacterized LOC137495265 Neighboring gene uncharacterized LOC110439710

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis. Lv Y, et al. J Biol Chem, 2024 Mar. PMID 38382674, Free PMC Article
    2. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within kinetochore assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centromere protein K
    Names
    SoxLZ/Sox6 leucine zipper binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256665.2 → NP_001243594.2  centromere protein K

      Status: VALIDATED

      Source sequence(s)
      CT573247
      UniProtKB/TrEMBL
      A0A8M1NZ19
      Related
      ENSDARP00000123524.1, ENSDART00000146567.3
      Conserved Domains (1) summary
      pfam11802
      Location:17 → 274
      CENP-K; Centromere-associated protein K

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      31508735..31516148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068220401.1 → XP_068076502.1  centromere protein K isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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