etfdh electron transfer flavoprotein dehydrogenase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: etfdhprovided by ZNC
Official Full Name: electron transfer flavoprotein dehydrogenaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040912-168
See related: Ensembl:ENSDARG00000038834 AllianceGenome:ZFIN:ZDB-GENE-040912-168
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa05a11; fb71g06; zgc:92093; wu:fa05a11; wu:fb71g06
Summary: Predicted to enable electron-transferring-flavoprotein dehydrogenase activity. Acts upstream of or within respiratory electron transport chain. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Used to study multiple acyl-CoA dehydrogenase deficiency. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFDH (electron transfer flavoprotein dehydrogenase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (48070872..48103153, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (49083115..49115453, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables electron-transferring-flavoprotein dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables electron-transferring-flavoprotein dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in electron transport chain	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within electron transport chain	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory electron transport chain	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

Names: electron-transferring-flavoprotein dehydrogenase; xav; xavier

NP_001004598.1

EC 1.5.5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004598.1 → NP_001004598.1 electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

See identical proteins and their annotated locations for NP_001004598.1

Status: PROVISIONAL

Source sequence(s)

BC081588

UniProtKB/TrEMBL

A0A8M1N289, Q66I16

Related

ENSDARP00000056711.4, ENSDART00000056712.6

Conserved Domains (3) summary

COG0644
Location:67 → 529

FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]

pfam05187
Location:512 → 615

ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S

cl21454
Location:73 → 199

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins