eif2b2 eukaryotic translation initiation factor 2B, subunit 2 beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eif2b2provided by ZNC
Official Full Name: eukaryotic translation initiation factor 2B, subunit 2 betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2605
See related: Ensembl:ENSDARG00000041397 AllianceGenome:ZFIN:ZDB-GENE-040426-2605
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77512
Summary: Predicted to enable translation initiation factor activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in brain and eye. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter and leukoencephalopathy with vanishing white matter 2. Orthologous to human EIF2B2 (eukaryotic translation initiation factor 2B subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (46523078..46534127, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (46619358..46630483, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 2B complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: translation initiation factor eIF2B subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212903.1 → NP_998068.1 translation initiation factor eIF2B subunit beta

See identical proteins and their annotated locations for NP_998068.1

Status: PROVISIONAL

Source sequence(s)

BC067147

UniProtKB/TrEMBL

A0A8M1PIL4, Q6NXC7

Related

ENSDARP00000060688.2, ENSDART00000060689.5

Conserved Domains (2) summary

COG1184
Location:38 → 348

GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]

pfam01008
Location:37 → 337

IF-2B; Initiation factor 2 subunit family