l1camb L1 cell adhesion molecule, paralog b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: l1cambprovided by ZNC
Official Full Name: L1 cell adhesion molecule, paralog bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-512
See related: Ensembl:ENSDARG00000015025 AllianceGenome:ZFIN:ZDB-GENE-980526-512
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: L1.1; nadl1.1; wu:fa30h05
Summary: Predicted to enable cell-cell adhesion mediator activity. Involved in cartilage morphogenesis and positive regulation of gene expression. Acts upstream of or within axon regeneration. Predicted to be located in axonal growth cone. Predicted to be active in axon and plasma membrane. Is expressed in nervous system; pectoral fin; and pharyngeal arch. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to human L1CAM (L1 cell adhesion molecule). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (590756..637357, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (583330..624552, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

nadl1.1 interacts with Alcama during chondrogenesis, and is required for alcama rescue of neural crest differentiation in edn1-/- mutants.
Title: Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis.
L1.1 contributes to successful regrowth of axons from the brainstem and locomotor recovery after spinal cord transection in adult zebrafish.
Title: L1.1 is involved in spinal cord regeneration in adult zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fa30h05.s1 (e-PCR)
- UniSTS:202512

NADL1.1 (e-PCR)
- UniSTS:205434

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cartilage morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axonal growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neural cell adhesion molecule L1.1

Names: N-CAM-L1.1; NCAM-L1.1; neural adhesion molecule L1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131383.1 → NP_571458.1 neural cell adhesion molecule L1.1 precursor

See identical proteins and their annotated locations for NP_571458.1

Status: PROVISIONAL

Source sequence(s)

AY376855

UniProtKB/Swiss-Prot

Q90478

UniProtKB/TrEMBL

Q6U7I5

Related

ENSDARP00000121175.1, ENSDART00000132175.2

Conserved Domains (8) summary

cd05876
Location:265 → 335

Ig3_L1-CAM; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)

smart00408
Location:446 → 505

IGc2; Immunoglobulin C-2 Type

smart00060
Location:719 → 798

FN3; Fibronectin type 3 domain

smart00410
Location:344 → 426

IG_like; Immunoglobulin like

cd00063
Location:616 → 706

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:522 → 607

I-set; Immunoglobulin I-set domain

pfam13882
Location:1148 → 1233

Bravo_FIGEY; Bravo-like intracellular region

cl11960
Location:352 → 427

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

590756..637357 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068216667.1 → XP_068072768.1 neural cell adhesion molecule L1.1 isoform X1

UniProtKB/Swiss-Prot

Q90478
XM_009296546.4 → XP_009294821.1 neural cell adhesion molecule L1.1 isoform X2

UniProtKB/Swiss-Prot

Q90478

UniProtKB/TrEMBL

A0A8M3AY05

Conserved Domains (9) summary

cd00096
Location:363 → 432

Ig; Immunoglobulin domain

cd05876
Location:90 → 160

Ig3_L1-CAM; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)

smart00408
Location:271 → 330

IGc2; Immunoglobulin C-2 Type

smart00060
Location:544 → 623

FN3; Fibronectin type 3 domain

smart00410
Location:169 → 251

IG_like; Immunoglobulin like

cd00063
Location:441 → 531

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:347 → 432

I-set; Immunoglobulin I-set domain

pfam13882
Location:973 → 1058

Bravo_FIGEY; Bravo-like intracellular region

cl11960
Location:177 → 252

Ig; Immunoglobulin domain