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    rps4x ribosomal protein S4 X-linked [ Danio rerio (zebrafish) ]

    Gene ID: 449547, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rps4xprovided by ZNC
    Official Full Name
    ribosomal protein S4 X-linkedprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040927-19
    See related
    Ensembl:ENSDARG00000014690 AllianceGenome:ZFIN:ZDB-GENE-040927-19
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92076; wu:fa91h09
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within brain development and chordate embryonic development. Predicted to be located in cytoplasm; nucleolus; and ribosome. Predicted to be part of cytosolic small ribosomal subunit and small-subunit processome. Orthologous to several human genes including RPS4X (ribosomal protein S4 X-linked). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rps4x in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (51633814..51639640, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (51358745..51364570, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 36 Neighboring gene NHS-like 2 Neighboring gene Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 Neighboring gene histone deacetylase 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Soya-saponins induce intestinal inflammation and barrier dysfunction in juvenile turbot (Scophthalmus maximus). Gu M, et al. Fish Shellfish Immunol, 2018 Jun. PMID 29625242
    2. Oocyte-specific maternal Slbp2 is required for replication-dependent histone storage and early nuclear cleavage in zebrafish oogenesis and embryogenesis. He WX, et al. RNA, 2018 Dec. PMID 30185624, Free PMC Article
    3. Ribosomal protein gene knockdown causes developmental defects in zebrafish. Uechi T, et al. PLoS One, 2006 Dec 20. PMID 17183665, Free PMC Article
    4. Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1. Li YF, et al. PLoS Biol, 2022 Nov. PMID 36318514, Free PMC Article
    5. A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Ayobahan SU, et al. Sci Rep, 2019 Apr 29. PMID 31036921, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein eS4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005589.1 → NP_001005589.1  small ribosomal subunit protein eS4

      See identical proteins and their annotated locations for NP_001005589.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081584
      UniProtKB/Swiss-Prot
      Q642H9
      Related
      ENSDARP00000108089.2, ENSDART00000128917.3
      Conserved Domains (5) summary
      PLN00036
      Location:1 → 260
      PLN00036; 40S ribosomal protein S4; Provisional
      cd06087
      Location:175 → 229
      KOW_RPS4; KOW motif of Ribosomal Protein S4 (RPS4)
      pfam00900
      Location:95 → 169
      Ribosomal_S4e; Ribosomal family S4e
      pfam08071
      Location:3 → 39
      RS4NT; RS4NT (NUC023) domain
      pfam16121
      Location:212 → 259
      40S_S4_C; 40S ribosomal protein S4 C-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      51633814..51639640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222241.1 → XP_068078342.1  small ribosomal subunit protein eS4 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q642H9.3 GenPept UniProtKB/Swiss-Prot:Q642H9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.