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    elavl1b ELAV like RNA binding protein 1b [ Danio rerio (zebrafish) ]

    Gene ID: 30065, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elavl1bprovided by ZNC
    Official Full Name
    ELAV like RNA binding protein 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000210-17
    See related
    Ensembl:ENSDARG00000101744 AllianceGenome:ZFIN:ZDB-GENE-000210-17
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hug; fb72d01; fk65g02; wu:fb72d01; wu:fk65g02
    Summary
    Enables mRNA 3'-UTR binding activity. Predicted to be part of ribonucleoprotein complex. Orthologous to human ELAVL1 (ELAV like RNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See elavl1b in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (14955484..15001702, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (14897825..14944101, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496678 Neighboring gene uncharacterized LOC137496680 Neighboring gene uncharacterized LOC101883516 Neighboring gene uncharacterized LOC108191595

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Regulation of hub mRNA stability and translation by miR430 and the dead end protein promotes preferential expression in zebrafish primordial germ cells. Mickoleit M, et al. Dev Dyn, 2011 Mar. PMID 21337467
    2. RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish. Frese KS, et al. J Cell Sci, 2015 Aug 15. PMID 26116573, Free PMC Article
    3. Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1. Li X, et al. Blood, 2014 Feb 27. PMID 24425803, Free PMC Article
    4. Genome wide analysis of 3' UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish. Vejnar CE, et al. Genome Res, 2019 Jul. PMID 31227602, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ELAV-like protein 1b
    Names
    etID19626.11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308614.1 → NP_001295543.1  ELAV-like protein 1b isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is one aa shorter compared to isoform a.
      Source sequence(s)
      CR550302
      UniProtKB/TrEMBL
      A0A2R8Q8X4, A0A8M1P7K3
      Related
      ENSDARP00000149646.1, ENSDART00000186508.1
      Conserved Domains (3) summary
      cd12650
      Location:54 → 131
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      TIGR01661
      Location:52 → 359
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:276 → 359
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001308615.1 → NP_001295544.1  ELAV-like protein 1b isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      CR550302
      UniProtKB/TrEMBL
      A0A2R8QLQ0, A0A8M1P6J6
      Related
      ENSDARP00000156360.1, ENSDART00000193450.1
      Conserved Domains (3) summary
      cd12650
      Location:34 → 111
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      TIGR01661
      Location:32 → 339
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:256 → 339
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001308616.1 → NP_001295545.1  ELAV-like protein 1b isoform d

      See identical proteins and their annotated locations for NP_001295545.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses two alternate splice junctions and lacks an alternate exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      CR550302
      UniProtKB/TrEMBL
      A0A8M1P1Z3, Q9PTK4
      Related
      ENSDARP00000156836.1, ENSDART00000188961.1
      Conserved Domains (3) summary
      cd12650
      Location:17 → 94
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      TIGR01661
      Location:15 → 322
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:239 → 322
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_001308617.1 → NP_001295546.1  ELAV-like protein 1b isoform d

      See identical proteins and their annotated locations for NP_001295546.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses two alternate splice junctions compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      CR550302
      UniProtKB/TrEMBL
      A0A8M1P1Z3, Q9PTK4
      Related
      ENSDARP00000151944.1, ENSDART00000193904.1
      Conserved Domains (3) summary
      cd12650
      Location:17 → 94
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      TIGR01661
      Location:15 → 322
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:239 → 322
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. NM_001308618.1 → NP_001295547.1  ELAV-like protein 1b isoform e

      See identical proteins and their annotated locations for NP_001295547.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate exons compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 6 and 7 both encode the same isoform (e).
      Source sequence(s)
      CR550302
      UniProtKB/TrEMBL
      A0A0R4IWC9, A0A8M1P1I3
      Related
      ENSDARP00000141879.1, ENSDART00000169476.2
      Conserved Domains (2) summary
      cd12377
      Location:125 → 202
      RRM3_Hu; RNA recognition motif 3 in the Hu proteins family
      cl17169
      Location:1 → 73
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. NM_001308619.1 → NP_001295548.1  ELAV-like protein 1b isoform e

      See identical proteins and their annotated locations for NP_001295548.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an alternate exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 6 and 7 both encode the same isoform (e).
      Source sequence(s)
      CR550302
      UniProtKB/TrEMBL
      A0A0R4IWC9, A0A8M1P1I3
      Related
      ENSDARP00000153928.1, ENSDART00000183952.1
      Conserved Domains (2) summary
      cd12377
      Location:125 → 202
      RRM3_Hu; RNA recognition motif 3 in the Hu proteins family
      cl17169
      Location:1 → 73
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. NM_130909.2 → NP_570984.2  ELAV-like protein 1b isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      CR550302
      UniProtKB/TrEMBL
      A0A2R8QTX4, A0A8N7UZD7
      Related
      ENSDARP00000157323.1, ENSDART00000180049.1
      Conserved Domains (3) summary
      cd12650
      Location:55 → 132
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      TIGR01661
      Location:53 → 360
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:277 → 360
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      14955484..15001702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224100.1 → XP_068080201.1  ELAV-like protein 1b isoform X2

      UniProtKB/TrEMBL
      A0A8M1P1Z3, Q9PTK4
      Related
      ENSDARP00000130648.1, ENSDART00000171210.2

    2. XM_017358196.3 → XP_017213685.1  ELAV-like protein 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z8M3
    Nucleotide Protein Strain
    Heading Accession and Version

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