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    ctsk cathepsin K [ Danio rerio (zebrafish) ]

    Gene ID: 550475, updated on 22-Dec-2024

    Summary

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    Official Symbol
    ctskprovided by ZNC
    Official Full Name
    cathepsin Kprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-001205-4
    See related
    Ensembl:ENSDARG00000040251 AllianceGenome:ZFIN:ZDB-GENE-001205-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa95f03; wu:fb08b05; zgc:110367
    Summary
    Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Acts upstream of or within bone morphogenesis; cartilage development; and response to mechanical stimulus. Predicted to be located in plasma membrane. Predicted to be active in extracellular space and lysosome. Is expressed in several structures, including cardiovascular system; head; lateral line system; mesoderm; and pectoral fin. Human ortholog(s) of this gene implicated in pycnodysostosis. Orthologous to human CTSK (cathepsin K). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ctsk in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (29492994..29502549)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (29558371..29567926)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:ch211-113g11.6 Neighboring gene uncharacterized LOC137487914 Neighboring gene leucine rich repeat and Ig domain containing 4b Neighboring gene cathepsin S, ortholog2, tandem duplicate 1 Neighboring gene cathepsin S, ortholog 2, tandem duplicate 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylation. Kim HM, et al. Bone, 2020 Feb. PMID 31730830
    2. 3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease. Kague E, et al. Bone Res, 2021 Aug 31. PMID 34465741, Free PMC Article
    3. Laser-mediated osteoblast ablation triggers a pro-osteogenic inflammatory response regulated by reactive oxygen species and glucocorticoid signaling in zebrafish. Geurtzen K, et al. Development, 2022 Apr 15. PMID 35485304
    4. Clinical pathologies of bone fracture modelled in zebrafish. Tomecka MJ, et al. Dis Model Mech, 2019 Sep 3. PMID 31383797, Free PMC Article
    5. An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio. Parichy DM, et al. Development, 2000 Jul. PMID 10862741

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inappropriate cathepsin K secretion promotes its enzymatic activation driving heart and valve malformation.
      Title: Inappropriate cathepsin K secretion promotes its enzymatic activation driving heart and valve malformation.
    2. components of the large latent TGFss complex were identified as novel targets of cathepsin K at neutral pH.
      Title: Cathepsin-Mediated Alterations in TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cartilage development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to mechanical stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cathepsin K
    Names
    etID33526.16
    NP_001017778.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017778.1 → NP_001017778.1  cathepsin K precursor

      See identical proteins and their annotated locations for NP_001017778.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092901
      UniProtKB/TrEMBL
      Q568D6
      Related
      ENSDARP00000007535.7, ENSDART00000011497.8
      Conserved Domains (2) summary
      smart00848
      Location:30 → 89
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:118 → 332
      Peptidase_C1; Papain family cysteine protease

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      29492994..29502549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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