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    zdhhc5a zinc finger DHHC-type palmitoyltransferase 5a [ Danio rerio (zebrafish) ]

    Gene ID: 571795, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zdhhc5aprovided by ZNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 5aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090312-92
    See related
    Ensembl:ENSDARG00000016263 AllianceGenome:ZFIN:ZDB-GENE-090312-92
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    DHHC-5A; si:dkey-28b4.5
    Summary
    Predicted to enable palmitoyltransferase activity. Predicted to be involved in positive regulation of pattern recognition receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in telencephalon. Orthologous to human ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See zdhhc5a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (44523524..44566433)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (43822193..43865130)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene crystallin, beta B1, like 2 Neighboring gene reticulon 4 receptor-like 2 a Neighboring gene thioredoxin-related transmembrane protein 2b Neighboring gene mediator complex subunit 19b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 2-Bromopalmitate impairs neural stem/progenitor cell proliferation, promotes cell apoptosis and induces malformation in zebrafish embryonic brain. Wang C, et al. Neurotoxicol Teratol, 2015 Jul-Aug. PMID 26056731
    2. Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Du Z, et al. Biochem Biophys Res Commun, 2016 Jun 24. PMID 27235108
    3. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of pattern recognition receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC5-A
    Names
    membrane-associated DHHC5 zinc finger protein
    palmitoyltransferase ZDHHC5a
    zinc finger DHHC domain-containing protein 5-A
    zinc finger DHHC-type containing 5a
    NP_001034729.1
    XP_005160301.1
    XP_068076733.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039640.1 → NP_001034729.1  palmitoyltransferase ZDHHC5-A

      See identical proteins and their annotated locations for NP_001034729.1

      Status: PROVISIONAL

      Source sequence(s)
      AY871210
      UniProtKB/Swiss-Prot
      Q2THW0
      Related
      ENSDARP00000009029.9, ENSDART00000003497.11
      Conserved Domains (1) summary
      pfam01529
      Location:116 → 241
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      44523524..44566433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160244.5 → XP_005160301.1  palmitoyltransferase ZDHHC5-A isoform X1

      UniProtKB/TrEMBL
      A0A8M2B731
      Conserved Domains (1) summary
      pfam01529
      Location:116 → 241
      zf-DHHC; DHHC palmitoyltransferase

    2. XM_068220632.1 → XP_068076733.1  palmitoyltransferase ZDHHC5-A isoform X2

      UniProtKB/Swiss-Prot
      Q2THW0
      Related
      ENSDARP00000123884.1, ENSDART00000147702.4

    RNA

    1. XR_222664.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2THW0.1 GenPept UniProtKB/Swiss-Prot:Q2THW0

    Gene LinkOut

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