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    ampd2b adenosine monophosphate deaminase 2b [ Danio rerio (zebrafish) ]

    Gene ID: 571355, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ampd2bprovided by ZNC
    Official Full Name
    adenosine monophosphate deaminase 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070713-5
    See related
    Ensembl:ENSDARG00000029952 AllianceGenome:ZFIN:ZDB-GENE-070713-5
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ampd2; fb72d11; wu:fb72d11
    Summary
    Predicted to enable AMP deaminase activity. Predicted to be involved in AMP metabolic process and IMP biosynthetic process. Predicted to act upstream of or within purine ribonucleoside monophosphate biosynthetic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 63 and pontocerebellar hypoplasia type 9. Orthologous to human AMPD2 (adenosine monophosphate deaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ampd2b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (25247245..25291981)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (25218535..25274515)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 Neighboring gene guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 Neighboring gene glutathione S-transferase mu, tandem duplicate 1 Neighboring gene glutathione S-transferase mu tandem duplicate 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Eumetazoan cryptochrome phylogeny and evolution. Haug MF, et al. Genome Biol Evol, 2015 Jan 18. PMID 25601102, Free PMC Article
    2. Many genes in fish have species-specific asymmetric rates of molecular evolution. Steinke D, et al. BMC Genomics, 2006 Feb 8. PMID 16466575, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables AMP deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within IMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in IMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine ribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AMP deaminase 2
    Names
    adenosine monophosphate deaminase 2 (isoform L)
    XP_005167171.1
    XP_005167172.1
    XP_005167173.1
    XP_009302285.3
    XP_021334119.1
    XP_021334120.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      25247245..25291981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478444.2 → XP_021334119.1  AMP deaminase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QA40
      Conserved Domains (1) summary
      cd01319
      Location:291 → 787
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

    2. XM_021478445.2 → XP_021334120.1  AMP deaminase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M9QIZ0
      Conserved Domains (1) summary
      cd01319
      Location:290 → 786
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

    3. XM_009304010.4 → XP_009302285.3  AMP deaminase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AV69
      Conserved Domains (1) summary
      cd01319
      Location:307 → 803
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

    4. XM_005167115.5 → XP_005167172.1  AMP deaminase 2 isoform X4

      See identical proteins and their annotated locations for XP_005167172.1

      UniProtKB/TrEMBL
      A0A8M2BEJ7, B8JIS9, F1R3S4
      Conserved Domains (2) summary
      PLN03055
      Location:182 → 737
      PLN03055; AMP deaminase; Provisional
      cd01319
      Location:233 → 729
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

    5. XM_005167116.5 → XP_005167173.1  AMP deaminase 2 isoform X4

      See identical proteins and their annotated locations for XP_005167173.1

      UniProtKB/TrEMBL
      A0A8M2BEJ7, B8JIS9, F1R3S4
      Conserved Domains (2) summary
      PLN03055
      Location:182 → 737
      PLN03055; AMP deaminase; Provisional
      cd01319
      Location:233 → 729
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

    6. XM_005167114.5 → XP_005167171.1  AMP deaminase 2 isoform X4

      See identical proteins and their annotated locations for XP_005167171.1

      UniProtKB/TrEMBL
      A0A8M2BEJ7, B8JIS9, F1R3S4
      Related
      ENSDARP00000113217.1, ENSDART00000143554.2
      Conserved Domains (2) summary
      PLN03055
      Location:182 → 737
      PLN03055; AMP deaminase; Provisional
      cd01319
      Location:233 → 729
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
    Nucleotide Protein Strain
    Heading Accession and Version

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