gata2a GATA binding protein 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gata2aprovided by ZNC
Official Full Name: GATA binding protein 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-260
See related: Ensembl:ENSDARG00000059327 AllianceGenome:ZFIN:ZDB-GENE-980526-260
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zg2; gata2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within circulatory system development; hemopoiesis; and ventral spinal cord interneuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including hematopoietic system; mesoderm; nervous system; presumptive structure; and trunk vasculature. Human ortholog(s) of this gene implicated in acute myeloid leukemia; depressive disorder; immunodeficiency 21; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (3847883..3865540, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (3828496..3846256, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency.
Title: Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency.
Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish.
Title: Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish.
Single-cell ATAC-seq reveals GATA2-dependent priming defect in myeloid and a maturation bottleneck in lymphoid lineages.
Title: Single-cell ATAC-seq reveals GATA2-dependent priming defect in myeloid and a maturation bottleneck in lymphoid lineages.
Enrichment of hematopoietic stem/progenitor cells in the zebrafish kidney.
Title: Enrichment of hematopoietic stem/progenitor cells in the zebrafish kidney.
Our results indicate that Kzp is a critical transcriptional factor for the expression of gata2 and pu.1 to modulate primitive hematopoiesis.
Title: Kzp regulates the transcription of gata2 and pu.1 during primitive hematopoiesis in zebrafish embryos.
Sox4b is expressed in zebrafish during pituitary development and plays a crucial role in the differentiation of thyrotrope and gonadotrope cells through induction of gata2a expression
Title: The HMG-box transcription factor Sox4b is required for pituitary expression of gata2a and specification of thyrotrope and gonadotrope cells in zebrafish.
gata2 down-regulation is pivotal for miR-451-driven erythroid maturation
Title: miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2.
we have identified a 224 bps cis-acting element that is sufficient to drive reporter gene expression in a manner that recapitulates hematopoietic GATA-2 expression pattern in a stable transgenic zebrafish line
Title: A highly conserved regulatory element controls hematopoietic expression of GATA-2 in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

gata2 (e-PCR), detects polymorphism
- UniSTS:186962

U18312 (e-PCR)
- UniSTS:187071

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrioventricular valve formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dorsal aorta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myeloid cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of miRNA transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within primitive hemopoiesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within regulation of myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ventral spinal cord interneuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endothelial transcription factor GATA-2a

Names: GATA-binding protein 2; gta2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131233.1 → NP_571308.1 endothelial transcription factor GATA-2a

See identical proteins and their annotated locations for NP_571308.1

Status: PROVISIONAL

Source sequence(s)

BC053131

UniProtKB/TrEMBL

A0A8N7UZH9, F1QT93, Q7T3G1

Related

ENSDARP00000076860.3, ENSDART00000082425.5

Conserved Domains (2) summary

smart00401
Location:320 → 369

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:325 → 373

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007122.7 Reference GRCz11 Primary Assembly

Range

3847883..3865540 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009305782.4 → XP_009304057.1 endothelial transcription factor GATA-2a isoform X1

See identical proteins and their annotated locations for XP_009304057.1

UniProtKB/TrEMBL

A0A2R9YJP8, A0A8M3AXB8

Conserved Domains (2) summary

smart00401
Location:324 → 373

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:329 → 377

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_009305781.4 → XP_009304056.1 endothelial transcription factor GATA-2a isoform X1

See identical proteins and their annotated locations for XP_009304056.1

UniProtKB/TrEMBL

A0A2R9YJP8, A0A8M3AXB8

Related

ENSDARP00000076855.4, ENSDART00000082420.4

Conserved Domains (2) summary

smart00401
Location:324 → 373

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:329 → 377

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_068224106.1 → XP_068080207.1 endothelial transcription factor GATA-2a isoform X3
XM_021479548.2 → XP_021335223.1 endothelial transcription factor GATA-2a isoform X2

UniProtKB/TrEMBL

A0A8M9Q709

Conserved Domains (1) summary

cd00202
Location:266 → 314

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C