slc25a12 solute carrier family 25 member 12 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc25a12provided by ZNC
Official Full Name: solute carrier family 25 member 12provided by ZNC
Primary source: ZFIN:ZDB-GENE-031006-11
See related: Ensembl:ENSDARG00000102362 AllianceGenome:ZFIN:ZDB-GENE-031006-11
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb929; cb1094; zgc:66248; wu:fj94c07
Summary: Predicted to enable L-aspartate transmembrane transporter activity and L-glutamate transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport; aspartate transmembrane transport; and malate-aspartate shuttle. Predicted to act upstream of or within transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is expressed in several structures, including anterior neural keel; central nervous system; neural plate; neural tube; and pronephros. Human ortholog(s) of this gene implicated in Asperger syndrome; autistic disorder; and developmental and epileptic encephalopathy 39. Orthologous to human SLC25A12 (solute carrier family 25 member 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (3961319..3982783, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (3800499..3821963, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables L-aspartate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-glutamate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in aspartate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in malate-aspartate shuttle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: calcium-binding mitochondrial carrier protein Aralar1

Names: Aralar; solute carrier family 25 (aspartate/glutamate carrier), member 12; solute carrier family 25 (mitochondrial carrier, Aralar), member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212782.1 → NP_997947.1 calcium-binding mitochondrial carrier protein Aralar1

See identical proteins and their annotated locations for NP_997947.1

Status: PROVISIONAL

Source sequence(s)

BC057495

UniProtKB/TrEMBL

Q6PFM3

Related

ENSDARP00000135288.1, ENSDART00000171944.2

Conserved Domains (3) summary

PTZ00169
Location:332 → 607

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:516 → 608

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:16 → 81

EF-hand_7; EF-hand domain pair