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    wnt10a wingless-type MMTV integration site family, member 10a [ Danio rerio (zebrafish) ]

    Gene ID: 30171, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wnt10aprovided by ZNC
    Official Full Name
    wingless-type MMTV integration site family, member 10aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-278
    See related
    Ensembl:ENSDARG00000017155 AllianceGenome:ZFIN:ZDB-GENE-990415-278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    WNT-10A
    Summary
    Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within odontogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in caudal fin and nervous system. Human ortholog(s) of this gene implicated in Schopf-Schulz-Passarge syndrome; ectodermal dysplasia; and tooth agenesis. Orthologous to human WNT10A (Wnt family member 10A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wnt10a in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (11379859..11409691)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (11408656..11438488)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene chondroitin polymerizing factor a Neighboring gene wingless-type MMTV integration site family, member 6b Neighboring gene cyclin dependent kinase 5, regulatory subunit 2b (p39) Neighboring gene microRNA mir-1788 Neighboring gene FEV transcription factor, ETS family member

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis. Benard EL, et al. Dev Dyn, 2024 Jun. PMID 37870737,
    2. V-ATPase proton pumping activity is required for adult zebrafish appendage regeneration. Monteiro J, et al. PLoS One, 2014. PMID 24671205, Free PMC Article
    3. Polarization and migration in the zebrafish posterior lateral line system. Knutsdottir H, et al. PLoS Comput Biol, 2017 Apr. PMID 28369079, Free PMC Article
    4. Role of WNT10A in failure of tooth development in humans and zebrafish. Yuan Q, et al. Mol Genet Genomic Med, 2017 Nov. PMID 29178643, Free PMC Article
    5. Inhibition of H3K9me2 Reduces Hair Cell Regeneration after Hair Cell Loss in the Zebrafish Lateral Line by Down-Regulating the Wnt and Fgf Signaling Pathways. Tang D, et al. Front Mol Neurosci, 2016. PMID 27303264, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis.
      Title: wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within odontogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein Wnt-10a
    Names
    etID309718.9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130980.1 → NP_571055.1  protein Wnt-10a

      Status: VALIDATED

      Source sequence(s)
      CR847976
      UniProtKB/Swiss-Prot
      P43446
      UniProtKB/TrEMBL
      A0A8N1Z0N8, B0V1G8
      Related
      ENSDARP00000005680.8, ENSDART00000007308.9
      Conserved Domains (1) summary
      cd19355
      Location:95 → 442
      Wnt_Wnt10a; Wnt domain found in protein Wnt-10a and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      11379859..11409691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43446.1 GenPept UniProtKB/Swiss-Prot:P43446

    Gene LinkOut

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