efcab7 EF-hand calcium binding domain 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: efcab7provided by ZNC
Official Full Name: EF-hand calcium binding domain 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-040625-115
See related: Ensembl:ENSDARG00000020279 AllianceGenome:ZFIN:ZDB-GENE-040625-115
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc67a03; zgc:86807; wu:fc67a03
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in positive regulation of protein localization to ciliary membrane. Predicted to be part of plasma membrane protein complex. Predicted to be active in ciliary membrane. Orthologous to human EFCAB7 (EF-hand calcium binding domain 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (32029231..32045951, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (32042317..32059037, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of protein localization to ciliary membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in ciliary membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of plasma membrane protein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: EF-hand calcium-binding domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002120.1 → NP_001002120.1 EF-hand calcium-binding domain-containing protein 7

See identical proteins and their annotated locations for NP_001002120.1

Status: PROVISIONAL

Source sequence(s)

BC071468

UniProtKB/TrEMBL

Q6IQD9

Related

ENSDARP00000014030.5, ENSDART00000016629.7

Conserved Domains (4) summary

cd00051
Location:80 → 141

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:81 → 141

EF-hand_7; EF-hand domain pair

pfam13833
Location:57 → 100

EF-hand_8; EF-hand domain pair

cl08302
Location:380 → 439

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...