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    psmc3 proteasome 26S subunit, ATPase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 321947, updated on 9-Dec-2024

    Summary

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    Official Symbol
    psmc3provided by ZNC
    Official Full Name
    proteasome 26S subunit, ATPase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-666
    See related
    Ensembl:ENSDARG00000007141 AllianceGenome:ZFIN:ZDB-GENE-030131-666
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:86713; wu:fb39a02
    Summary
    Predicted to enable proteasome-activating activity. Involved in lens development in camera-type eye and semicircular canal fusion. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, base subcomplex. Is expressed in inner ear. Used to study cataract and sensorineural hearing loss. Orthologous to human PSMC3 (proteasome 26S subunit, ATPase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See psmc3 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (38680044..38685154)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (38408734..38413896)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene six-cysteine containing astacin protease 1 Neighboring gene mitochondrial carrier homolog 2 Neighboring gene uncharacterized LOC137496187 Neighboring gene apelin receptor 2 Neighboring gene CD59 molecule (CD59 blood group) a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress. Kröll-Hermi A, et al. EMBO Mol Med, 2020 Jul 7. PMID 32500975, Free PMC Article
    2. Screening Study on the Anti-Angiogenic Effects of Traditional Chinese Medicine - Part II: Wild Chrysanthemum. Tu X, et al. J Cancer, 2021. PMID 33391408, Free PMC Article
    3. Comparative analysis of the PDCD2-TBP-PSMB1 region in vertebrates. Trachtulec Z, et al. Gene, 2004 Jun 23. PMID 15194198
    4. Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation. Ung CY, et al. BMC Genomics, 2010 Mar 30. PMID 20353558, Free PMC Article
    5. Tissue Extract Fractions from Starfish Undergoing Regeneration Promote Wound Healing and Lower Jaw Blastema Regeneration of Zebrafish. Dai Y, et al. Sci Rep, 2016 Dec 15. PMID 27974833, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress.
      Title: Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome-activating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in semicircular canal fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    26S proteasome regulatory subunit 6A
    Names
    proteasome (prosome, macropain) 26S subunit, ATPase, 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002064.1 → NP_001002064.1  26S proteasome regulatory subunit 6A

      See identical proteins and their annotated locations for NP_001002064.1

      Status: PROVISIONAL

      Source sequence(s)
      BC071390
      UniProtKB/TrEMBL
      Q6IQL5
      Related
      ENSDARP00000026554.8, ENSDART00000007913.12
      Conserved Domains (2) summary
      COG1222
      Location:9 → 397
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
      pfam00004
      Location:188 → 320
      AAA; ATPase family associated with various cellular activities (AAA)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      38680044..38685154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168962.5 → XP_005169019.1  26S proteasome regulatory subunit 6A isoform X1

      UniProtKB/TrEMBL
      A0A0R4ILA8, A0A8M2BG93
      Related
      ENSDARP00000136258.1, ENSDART00000171691.2
      Conserved Domains (1) summary
      COG1222
      Location:12 → 420
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]

    2. XM_005168963.5 → XP_005169020.1  26S proteasome regulatory subunit 6A isoform X2

      UniProtKB/TrEMBL
      A0A8M2BGA0
      Conserved Domains (2) summary
      COG1222
      Location:12 → 418
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
      pfam00004
      Location:209 → 341
      AAA; ATPase family associated with various cellular activities (AAA)
    Nucleotide Protein
    Heading Accession and Version

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