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    eif4bb eukaryotic translation initiation factor 4Bb [ Danio rerio (zebrafish) ]

    Gene ID: 336619, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eif4bbprovided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 4Bbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8563
    See related
    Ensembl:ENSDARG00000010194 AllianceGenome:ZFIN:ZDB-GENE-030131-8563
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    eif4b; fb15c09; wu:fb15c09; zgc:101532
    Summary
    Predicted to enable RNA binding activity. Predicted to act upstream of or within translational initiation. Orthologous to human EIF4B (eukaryotic translation initiation factor 4B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eif4bb in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (39064824..39080630, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (39067288..39083160, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene tensin 2b Neighboring gene uncharacterized LOC137495994 Neighboring gene serine protease 60.1 Neighboring gene serine protease 60.2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative phosphoproteomics of zebrafish Fyn/Yes morpholino knockdown embryos. Lemeer S, et al. Mol Cell Proteomics, 2008 Nov. PMID 18550893
    2. Tissue Extract Fractions from Starfish Undergoing Regeneration Promote Wound Healing and Lower Jaw Blastema Regeneration of Zebrafish. Dai Y, et al. Sci Rep, 2016 Dec 15. PMID 27974833, Free PMC Article
    3. Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Ozbudak EM, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160088, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC101532

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA strand annealing activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA strand-exchange activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in eukaryotic translation initiation factor 4F complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4Bb
    Names
    eukaryotic translation initiation factor 4B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214718.1 → NP_999883.1  eukaryotic translation initiation factor 4Bb

      See identical proteins and their annotated locations for NP_999883.1

      Status: PROVISIONAL

      Source sequence(s)
      AY576997
      UniProtKB/TrEMBL
      Q6PUR8
      Related
      ENSDARP00000008894.8, ENSDART00000021520.10
      Conserved Domains (2) summary
      COG0724
      Location:91 → 246
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12402
      Location:95 → 171
      RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      39064824..39080630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068221656.1 → XP_068077757.1  eukaryotic translation initiation factor 4Bb isoform X4

    2. XM_068221655.1 → XP_068077756.1  eukaryotic translation initiation factor 4Bb isoform X2

    3. XM_021476791.2 → XP_021332466.1  eukaryotic translation initiation factor 4Bb isoform X3

      UniProtKB/TrEMBL
      A0A8M9QA66
      Conserved Domains (3) summary
      PTZ00459
      Location:429 → 538
      PTZ00459; mucin-associated surface protein (MASP); Provisional
      cd12402
      Location:95 → 171
      RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins
      cl25574
      Location:307 → 538
      TOP2c; TopoisomeraseII

    4. XM_005166014.5 → XP_005166071.1  eukaryotic translation initiation factor 4Bb isoform X1

      UniProtKB/TrEMBL
      A0A8M2BDG2, F1Q8G3
      Related
      ENSDARP00000105821.2, ENSDART00000128308.4
      Conserved Domains (2) summary
      COG0724
      Location:91 → 246
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12402
      Location:95 → 171
      RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394660.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      162274..178837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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