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    birc2 baculoviral IAP repeat containing 2 [ Danio rerio (zebrafish) ]

    Gene ID: 373107, updated on 9-Dec-2024

    Summary

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    Official Symbol
    birc2provided by ZNC
    Official Full Name
    baculoviral IAP repeat containing 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030825-6
    See related
    Ensembl:ENSDARG00000044619 AllianceGenome:ZFIN:ZDB-GENE-030825-6
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    IAP1; birc3
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of programmed cell death; positive regulation of protein ubiquitination; and regulation of cell cycle. Predicted to act upstream of or within regulation of apoptotic process. Predicted to be active in cytoplasm and nucleus. Is expressed in dorsal aorta; intersegmental vessel; and posterior cardinal vein. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. Orthologous to several human genes including BIRC2 (baculoviral IAP repeat containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See birc2 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (22833889..22851099)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (22797302..22814623)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 6a Neighboring gene angiopoietin-like 5 Neighboring gene cilia and flagella associated protein 300 Neighboring gene polymerase (DNA directed), theta Neighboring gene DNA damage-induced apoptosis suppressor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Santoro MM, et al. Nat Genet, 2007 Nov. PMID 17934460
    2. The Zebrafish Antiapoptotic Protein BIRC2 Promotes Edwardsiella piscicida Infection by Inhibiting Caspases and Accumulating p53 in a p53 Transcription-Dependent and -Independent Manner. Cao L, et al. Front Immunol, 2021. PMID 34887869, Free PMC Article
    3. yap1b, a divergent Yap/Taz family member, cooperates with yap1 in survival and morphogenesis via common transcriptional targets. Vázquez-Marín J, et al. Development, 2019 Jun 21. PMID 31142542
    4. The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2. Essers PB, et al. Oncogene, 2015 Feb 5. PMID 24469044
    5. Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio). Hu J, et al. Int J Biol Sci, 2013. PMID 23494967, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of necroptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    baculoviral IAP repeat-containing protein 2
    Names
    bZ1P14.6.2 (baculoviral IAP repeat-containing 3 )
    baculoviral IAP repeat-containing 3
    NP_919376.1
    XP_005161213.1
    XP_017208244.1
    XP_068071910.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194395.4 → NP_919376.1  baculoviral IAP repeat-containing protein 2

      See identical proteins and their annotated locations for NP_919376.1

      Status: VALIDATED

      Source sequence(s)
      CU695000
      UniProtKB/TrEMBL
      Q1RLX5, Q8UWD2
      Related
      ENSDARP00000065554.5, ENSDART00000065555.6
      Conserved Domains (5) summary
      smart00238
      Location:187 → 255
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:280 → 347
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd08329
      Location:463 → 554
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:401 → 447
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      pfam13920
      Location:577 → 622
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      22833889..22851099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161156.5 → XP_005161213.1  baculoviral IAP repeat-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005161213.1

      UniProtKB/TrEMBL
      A0A8M3ALE6, Q7T0K2
      Related
      ENSDARP00000103254.3, ENSDART00000111150.5
      Conserved Domains (5) summary
      smart00238
      Location:206 → 274
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:299 → 366
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd08329
      Location:482 → 573
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:420 → 466
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      pfam13920
      Location:596 → 641
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    2. XM_068215809.1 → XP_068071910.1  baculoviral IAP repeat-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3ALE6, Q7T0K2

    3. XM_017352755.3 → XP_017208244.1  baculoviral IAP repeat-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A2R8QDZ3, A0A8M6YUF8
      Related
      ENSDARP00000151933.1, ENSDART00000185766.1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395091.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      263498..271858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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