U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    vav2 vav 2 guanine nucleotide exchange factor [ Danio rerio (zebrafish) ]

    Gene ID: 556413, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    vav2provided by ZNC
    Official Full Name
    vav 2 guanine nucleotide exchange factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091204-420
    See related
    Ensembl:ENSDARG00000044718 AllianceGenome:ZFIN:ZDB-GENE-091204-420
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wan; si:dkeyp-116h7.3
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within fin morphogenesis. Predicted to be active in cytoplasm. Is expressed in heart and pectoral fin bud. Orthologous to human VAV2 (vav guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See vav2 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (18022875..18263198, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (17986241..18226593, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438227 Neighboring gene uncharacterized LOC137488794 Neighboring gene uncharacterized LOC137488795 Neighboring gene bromodomain containing 3a Neighboring gene WD repeat domain 5

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Next-generation sequencing identifies novel genes with rare variants in total anomalous pulmonary venous connection. Shi X, et al. EBioMedicine, 2018 Dec. PMID 30448225, Free PMC Article
    2. Latent developmental potential to form limb-like skeletal structures in zebrafish. Hawkins MB, et al. Cell, 2021 Feb 18. PMID 33545089
    3. Mutations affecting pigmentation and shape of the adult zebrafish. Haffter P, et al. Dev Genes Evol, 1996 Nov. PMID 24173565
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    guanine nucleotide exchange factor VAV2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      18022875..18263198 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216026.1 → XP_068072127.1  guanine nucleotide exchange factor VAV2 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PIU4

    2. XM_009295361.4 → XP_009293636.1  guanine nucleotide exchange factor VAV2 isoform X8

      UniProtKB/TrEMBL
      A0A8M3ATW1, A0A8M9PIU4
      Related
      ENSDARP00000122666.1, ENSDART00000143987.2
      Conserved Domains (8) summary
      cd10406
      Location:659 → 761
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:782 → 839
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd00029
      Location:515 → 558
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:385 → 507
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:402 → 503
      PH; PH domain
      pfam00621
      Location:198 → 371
      RhoGEF; RhoGEF domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain
      cl17036
      Location:580 → 639
      SH3; Src Homology 3 domain superfamily

    3. XM_009295358.4 → XP_009293633.1  guanine nucleotide exchange factor VAV2 isoform X5

      UniProtKB/TrEMBL
      A0A8M3AM66, A0A8M9P3P6
      Conserved Domains (8) summary
      cd10406
      Location:659 → 761
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:811 → 868
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd00029
      Location:515 → 558
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:385 → 507
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:402 → 503
      PH; PH domain
      pfam00621
      Location:198 → 371
      RhoGEF; RhoGEF domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain
      cl17036
      Location:580 → 639
      SH3; Src Homology 3 domain superfamily

    4. XM_009295357.4 → XP_009293632.1  guanine nucleotide exchange factor VAV2 isoform X3

      UniProtKB/TrEMBL
      A0A286Y8W8, A0A8M3B4P6, A0A8M9PUI9
      Related
      ENSDARP00000143602.1, ENSDART00000176716.2
      Conserved Domains (8) summary
      cd10406
      Location:664 → 766
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:816 → 873
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd00029
      Location:520 → 563
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:385 → 512
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:402 → 508
      PH; PH domain
      pfam00621
      Location:198 → 371
      RhoGEF; RhoGEF domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain
      cl17036
      Location:585 → 644
      SH3; Src Homology 3 domain superfamily

    5. XM_068216025.1 → XP_068072126.1  guanine nucleotide exchange factor VAV2 isoform X4

      UniProtKB/TrEMBL
      A0A8M9P3P6

    6. XM_009295356.4 → XP_009293631.1  guanine nucleotide exchange factor VAV2 isoform X2

      UniProtKB/TrEMBL
      A0A8M3ALG5, A0A8M9PR05
      Conserved Domains (8) summary
      cd10406
      Location:669 → 771
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:820 → 877
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd00029
      Location:525 → 568
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:390 → 517
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:407 → 513
      PH; PH domain
      pfam00621
      Location:203 → 376
      RhoGEF; RhoGEF domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain
      cl17036
      Location:590 → 649
      SH3; Src Homology 3 domain superfamily

    7. XM_017352942.3 → XP_017208431.1  guanine nucleotide exchange factor VAV2 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YV87, A0A8M9PUI9

    8. XM_009295360.4 → XP_009293635.1  guanine nucleotide exchange factor VAV2 isoform X7

      UniProtKB/TrEMBL
      A0A8M3AWV3, A0A8M9P3P6
      Conserved Domains (8) summary
      cd10406
      Location:659 → 761
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:810 → 867
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd00029
      Location:515 → 558
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:385 → 507
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:402 → 503
      PH; PH domain
      pfam00621
      Location:198 → 371
      RhoGEF; RhoGEF domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain
      cl17036
      Location:580 → 639
      SH3; Src Homology 3 domain superfamily

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395086.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      43438..213484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473408.2 → XP_021329083.2  guanine nucleotide exchange factor VAV2 isoform X9

      UniProtKB/TrEMBL
      A0A8M9PPX7
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools