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    arhgef12a Rho guanine nucleotide exchange factor (GEF) 12a [ Danio rerio (zebrafish) ]

    Gene ID: 562455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arhgef12aprovided by ZNC
    Official Full Name
    Rho guanine nucleotide exchange factor (GEF) 12aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-121017-3
    See related
    Ensembl:ENSDARG00000030532 AllianceGenome:ZFIN:ZDB-GENE-121017-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    arhgef12
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within erythrocyte differentiation. Predicted to be located in cytoplasm and membrane. Orthologous to human ARHGEF12 (Rho guanine nucleotide exchange factor 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See arhgef12a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (22446322..22537374)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (22510386..22601640)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene OAF homolog a (Drosophila) Neighboring gene TLC domain containing 5a Neighboring gene uncharacterized LOC103908836 Neighboring gene glutamate receptor, ionotropic, kainate 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage. Baek S, et al. Dev Cell, 2019 Apr 22. PMID 31014480
    2. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Xie Y, et al. Haematologica, 2020 Apr. PMID 31467124, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within erythrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 12
    Names
    Rho guanine nucleotide exchange factor (GEF) 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      22446322..22537374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009291731.4 → XP_009290006.1  rho guanine nucleotide exchange factor 12 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AHH6, E7FDV8
      Related
      ENSDARP00000040541.5, ENSDART00000040542.7
      Conserved Domains (4) summary
      cd00992
      Location:66 → 140
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00621
      Location:743 → 928
      RhoGEF; RhoGEF domain
      cl02565
      Location:308 → 524
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:947 → 1083
      PH-like; Pleckstrin homology-like domain

    2. XM_009291733.4 → XP_009290008.1  rho guanine nucleotide exchange factor 12 isoform X3

      UniProtKB/TrEMBL
      A0A2R8QD00, A0A8M3AIL3
      Related
      ENSDARP00000149601.1, ENSDART00000190270.1
      Conserved Domains (4) summary
      cd00992
      Location:47 → 121
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00621
      Location:724 → 909
      RhoGEF; RhoGEF domain
      cl02565
      Location:289 → 505
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:928 → 1064
      PH-like; Pleckstrin homology-like domain

    3. XM_068213719.1 → XP_068069820.1  rho guanine nucleotide exchange factor 12 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B155
      Related
      ENSDARP00000152634.1, ENSDART00000185897.1
    Nucleotide Protein Strain
    Heading Accession and Version

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