ak2 adenylate kinase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ak2provided by ZNC
Official Full Name: adenylate kinase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-512
See related: Ensembl:ENSDARG00000005926 AllianceGenome:ZFIN:ZDB-GENE-030131-512
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb34f05; wu:fj80e03
Summary: Predicted to enable adenylate kinase activity. Acts upstream of or within hematopoietic stem cell differentiation and leukocyte differentiation. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in mitochondrion. Is expressed in head; hematopoietic system; intermediate cell mass of mesoderm; and otic vesicle. Used to study reticular dysgenesis. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 19

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (35418683..35428894, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (35831563..35841787, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ak2 is required for the correct development, survival and regeneration of sensory hair cells
Title: A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress.
Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress.
Title: Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress.
Knockdown of zebrafish ak2 also leads to aberrant leukocyte development, stressing the evolutionarily conserved role of AK2.
Title: Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

AI436922 (e-PCR)
- UniSTS:206607

fj80e03.x1 (e-PCR)
- UniSTS:199961

fe38h05.x1 (e-PCR)
- UniSTS:196467

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleobase-containing compound kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphotransferase activity, phosphate group as acceptor	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ADP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ADP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ADP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in AMP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leukocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: adenylate kinase 2, mitochondrial

NP_997761.1

EC 2.7.4.3

XP_005159705.1

EC 2.7.4.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212596.1 → NP_997761.1 adenylate kinase 2, mitochondrial

See identical proteins and their annotated locations for NP_997761.1

Status: PROVISIONAL

Source sequence(s)

BC053160

UniProtKB/Swiss-Prot

Q1L8L9, Q7T3D7

Related

ENSDARP00000010686.4, ENSDART00000003167.5

Conserved Domains (2) summary

PRK00279
Location:19 → 231

adk; adenylate kinase; Reviewed

cd01428
Location:19 → 221

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

35418683..35428894 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159648.4 → XP_005159705.1 adenylate kinase 2, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_005159705.1

UniProtKB/Swiss-Prot

Q1L8L9, Q7T3D7

UniProtKB/TrEMBL

A0A0F6PK88, A0A8M2B693

Related

ENSDARP00000131617.1, ENSDART00000169006.2

Conserved Domains (2) summary

PRK00279
Location:19 → 231

adk; adenylate kinase; Reviewed

cd01428
Location:19 → 221

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...