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    ikzf5 IKAROS family zinc finger 5 [ Danio rerio (zebrafish) ]

    Gene ID: 402893, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ikzf5provided by ZNC
    Official Full Name
    IKAROS family zinc finger 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-209
    See related
    Ensembl:ENSDARG00000056491 AllianceGenome:ZFIN:ZDB-GENE-040801-209
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92405; wu:fb55f09
    Summary
    Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within determination of intestine left/right asymmetry; determination of left/right asymmetry in lateral mesoderm; and determination of pancreatic left/right asymmetry. Predicted to be located in nucleus. Is expressed in several structures, including brain; digestive system; eye; pharyngeal arch cartilage; and thymus. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human IKZF5 (IKAROS family zinc finger 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ikzf5 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (21817391..21822198)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (21797542..21802362)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene H6 family homeobox 2 Neighboring gene H6 family homeobox 3a Neighboring gene interferon induced protein 44e Neighboring gene CUB and zona pellucida-like domains 1, tandem duplicate 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Pegasus, the 'atypical' Ikaros family member, influences left-right asymmetry and regulates pitx2 expression. John LB, et al. Dev Biol, 2013 May 1. PMID 23499657
    2. Evolution of the Ikaros gene family: implications for the origins of adaptive immunity. John LB, et al. J Immunol, 2009 Apr 15. PMID 19342657
    3. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pitx2, implicated in left-right asymmetry, possessed appropriate 'atypical' Pegasus binding sites in its promoter.
      Title: Pegasus, the 'atypical' Ikaros family member, influences left-right asymmetry and regulates pitx2 expression.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within determination of intestine left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right asymmetry in lateral mesoderm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of pancreatic left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein Pegasus
    Names
    ikaros family zinc finger protein 5
    pegasus
    zinc finger protein subfamily 1A 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205601.1 → NP_991164.1  zinc finger protein Pegasus

      Status: PROVISIONAL

      Source sequence(s)
      AY394931
      UniProtKB/TrEMBL
      C4XVB6
      Related
      ENSDARP00000073468.4, ENSDART00000079011.6
      Conserved Domains (4) summary
      COG5048
      Location:105 → 163
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:81 → 101
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:368 → 388
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:121 → 145
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      21817391..21822198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009293021.4 → XP_009291296.1  zinc finger protein Pegasus isoform X1

      UniProtKB/Swiss-Prot
      Q6DBW0, Q6TLH4
      Related
      ENSDARP00000147344.1, ENSDART00000189387.1
      Conserved Domains (4) summary
      COG5048
      Location:105 → 163
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:81 → 101
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:368 → 388
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:121 → 145
      zf-H2C2_2; Zinc-finger double domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394986.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      64925..69732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DBW0.1 GenPept UniProtKB/Swiss-Prot:Q6DBW0

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