cdc25b cell division cycle 25B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cdc25bprovided by ZNC
Official Full Name: cell division cycle 25Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000330-5
See related: Ensembl:ENSDARG00000010792 AllianceGenome:ZFIN:ZDB-GENE-000330-5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cdc25; cdc25A; sb:cb317
Summary: Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within positive regulation of mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle; and regulation of mitotic cell cycle, embryonic. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including DEL; anterior neural keel; axis; nervous system; and optic vesicle. Human ortholog(s) of this gene implicated in autosomal recessive polycystic kidney disease; cervical cancer; endometrial cancer; prostate cancer; and urinary bladder cancer. Orthologous to several human genes including CDC25B (cell division cycle 25B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (14915332..14929161, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (14784340..14798169, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a expression during oogenesis. Accordingly, restoring Cdc25a expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
Title: Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation.

Submit: New GeneRIF Correction

General gene information

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Markers

fe49b11.x1 (e-PCR)
- UniSTS:204397

fe06b09.y1 (e-PCR)
- UniSTS:196014

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell cycle G2/M phase transition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mitotic cell cycle, embryonic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: M-phase inducer phosphatase 2

Names: cell division cycle 25 homolog; sds; standstill

NP_001108567.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001115095.2 → NP_001108567.1 M-phase inducer phosphatase 2

Status: VALIDATED

Source sequence(s)

CN014310, CT625637, CT708651, EH500454, EU921896, FP128795

UniProtKB/TrEMBL

A0A8N7UYT2, B5LY73, B8A5N7

Related

ENSDARP00000003494.6, ENSDART00000020576.9

Conserved Domains (2) summary

cd01530
Location:395 → 514

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

pfam06617
Location:104 → 366

M-inducer_phosp; M-phase inducer phosphatase