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    fanci FA complementation group I [ Danio rerio (zebrafish) ]

    Gene ID: 324185, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fanciprovided by ZNC
    Official Full Name
    FA complementation group Iprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2905
    See related
    Ensembl:ENSDARG00000026224 AllianceGenome:ZFIN:ZDB-GENE-030131-2905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc21c10; wu:fc21c10; zgc:152941
    Summary
    Predicted to enable DNA polymerase binding activity. Predicted to act upstream of or within DNA repair. Is expressed in central nervous system; head; heart; pectoral fin; and rostral blood island. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group I; and female breast cancer. Orthologous to human FANCI (FA complementation group I). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fanci in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (8447565..8479171)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (8370497..8402103)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene mucin 5.1, oligomeric mucus/gel-forming Neighboring gene mucin 5.2 Neighboring gene polymerase (DNA directed), gamma Neighboring gene uncharacterized LOC101885510 Neighboring gene transfer RNA arginine (anticodon UCG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. FANCI functions as a repair/apoptosis switch in response to DNA crosslinks. Shah RB, et al. Dev Cell, 2021 Aug 9. PMID 34256011, Free PMC Article
    2. The Fanconi anemia/BRCA gene network in zebrafish: embryonic expression and comparative genomics. Titus TA, et al. Mutat Res, 2009 Jul 31. PMID 19101574, Free PMC Article
    3. Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility. Ramanagoudr-Bhojappa R, et al. PLoS Genet, 2018 Dec. PMID 30540754, Free PMC Article
    4. Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. Shin U, et al. DNA Repair (Amst), 2021 Nov. PMID 34390914
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC152941

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Fanconi anemia group I protein
    Names
    Fanconi anemia, complementation group I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077312.2 → NP_001070780.2  Fanconi anemia group I protein

      Status: VALIDATED

      Source sequence(s)
      CR854881
      UniProtKB/TrEMBL
      A0A8M1NA61, F1R3B9
      Related
      ENSDARP00000116242.1, ENSDART00000142090.3
      Conserved Domains (2) summary
      cd11720
      Location:47 → 1295
      FANCI; Fanconi anemia I protein
      pfam14674
      Location:7 → 59
      FANCI_S1-cap; FANCI solenoid 1 cap

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      8447565..8479171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470451.2 → XP_021326126.1  Fanconi anemia group I protein isoform X1

      UniProtKB/TrEMBL
      A0A8M9PUU2
      Related
      ENSDART00000136530.2
      Conserved Domains (2) summary
      cd11720
      Location:47 → 1295
      FANCI; Fanconi anemia I protein
      pfam14674
      Location:7 → 59
      FANCI_S1-cap; FANCI solenoid 1 cap
    Nucleotide Protein
    Heading Accession and Version

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