sts steroid sulfatase (microsomal), isozyme S [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: stsprovided by ZNC
Official Full Name: steroid sulfatase (microsomal), isozyme Sprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030717-5
See related: Ensembl:ENSDARG00000053241 AllianceGenome:ZFIN:ZDB-GENE-030717-5
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-271l9.1
Summary: Enables steryl-sulfatase activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in X-linked ichthyosis. Orthologous to human STS (steroid sulfatase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (32051581..32077857)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (31318847..31345138)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the results obtained indicated that zebrafish Sts exhibited enzymatic characteristics comparable to the human STS, suggesting that the physiological function of STS may be conserved between zebrafish and humans.
Title: Identification of zebrafish steroid sulfatase and comparative analysis of the enzymatic properties with human steroid sulfatase.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables arylsulfatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables steryl-sulfatase activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: steryl-sulfatase

Names: steroid sulfatase (microsomal), arylsulfatase C, isozyme S

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

32051581..32077857

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005168397.5 → XP_005168454.1 steryl-sulfatase isoform X1

UniProtKB/TrEMBL

A0A8M2BFQ4, F1QB82

Related

ENSDARP00000118457.2, ENSDART00000146602.3

Conserved Domains (2) summary

PRK13759
Location:23 → 533

PRK13759; arylsulfatase; Provisional

cd16159
Location:25 → 546

ES; Estrone sulfatase

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394494.1 Reference GRCz11 ALT_DRER_TU_1

Range

2998..9654

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021471215.2 → XP_021326890.1 steryl-sulfatase isoform X2

UniProtKB/TrEMBL

A0A8M9Q0K6

Conserved Domains (1) summary

cl23718
Location:1 → 228

ALP_like; alkaline phosphatases and sulfatases