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    kif20a kinesin family member 20A [ Danio rerio (zebrafish) ]

    Gene ID: 325449, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kif20aprovided by ZNC
    Official Full Name
    kinesin family member 20Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-252
    See related
    Ensembl:ENSDARG00000044491 AllianceGenome:ZFIN:ZDB-GENE-050522-252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fi34h02; wu:fj10c11; zgc:112061
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within heart development. Predicted to be located in cytoskeleton. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm; microtubule; and nucleus. Human ortholog(s) of this gene implicated in restrictive cardiomyopathy. Orthologous to human KIF20A (kinesin family member 20A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kif20a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (34879268..34926619, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (34844778..34892129, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 55 Neighboring gene zgc:56585 Neighboring gene CDC23 (cell division cycle 23, yeast, homolog) Neighboring gene si:dkey-71d15.2 Neighboring gene lipase, member Ia

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings. Louw JJ, et al. PLoS Genet, 2018 Jan. PMID 29357359, Free PMC Article
    2. Metallothionein gene expression in zebrafish embryo-larvae and ZFL cell-line exposed to heavy metal ions. Chan KM, et al. Mar Environ Res, 2006 Jul. PMID 16690118
    3. Expression of mt2 and smt-B upon cadmium exposure and cold shock in zebrafish (Danio rerio). Wu SM, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2008 Aug. PMID 18579444
    4. Cloning of zebrafish metallothionein gene and characterization of its gene promoter region in HepG2 cell line. Yan CH, et al. Biochim Biophys Acta, 2004 Jul 13. PMID 15245916
    5. Dietary iron alters waterborne copper-induced gene expression in soft water acclimated zebrafish (Danio rerio). Craig PM, et al. Am J Physiol Regul Integr Comp Physiol, 2009 Feb. PMID 18987288

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Report expression of mt2 and smt-B upon cadmium exposure and cold shock in zebrafish (Danio rerio).
      Title: Expression of mt2 and smt-B upon cadmium exposure and cold shock in zebrafish (Danio rerio).
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112061

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF20A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161470.1 → NP_001154942.1  kinesin-like protein KIF20A

      Status: VALIDATED

      Source sequence(s)
      BC095661, BX957298
      UniProtKB/TrEMBL
      A0A8M1NT09, F1QDF0, Q502K6
      Related
      ENSDARP00000065336.4, ENSDART00000065337.5
      Conserved Domains (3) summary
      cl22853
      Location:77 → 510
      Motor_domain; Myosin and Kinesin motor domain
      pfam00225
      Location:84 → 510
      Kinesin; Kinesin motor domain
      pfam07851
      Location:572 → 661
      TMPIT; TMPIT-like protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      34879268..34926619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215787.1 → XP_068071888.1  kinesin-like protein KIF20A isoform X1

      UniProtKB/TrEMBL
      Q502K6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_194273.1: Suppressed sequence

      Description
      NM_194273.1: This RefSeq was permanently suppressed because it is based on a chimeric sequence.
    Nucleotide Protein
    Heading Accession and Version

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