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    cfap43 cilia and flagella associated protein 43 [ Danio rerio (zebrafish) ]

    Gene ID: 568701, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cfap43provided by ZNC
    Official Full Name
    cilia and flagella associated protein 43provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080815-3
    See related
    Ensembl:ENSDARG00000001825 AllianceGenome:ZFIN:ZDB-GENE-080815-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wdr96; gb:ee329193; si:ch211-223p8.5
    Summary
    Predicted to be involved in sperm axoneme assembly. Predicted to be located in cytoplasm and motile cilium. Predicted to be active in axoneme. Human ortholog(s) of this gene implicated in normal pressure hydrocephalus and spermatogenic failure 19. Orthologous to human CFAP43 (cilia and flagella associated protein 43). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cfap43 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (24717880..24743151)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (24587436..24612701)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene sperm flagellar 1 Neighboring gene ER lipid raft associated 1 Neighboring gene collagen, type XVII, alpha 1b Neighboring gene SWI5-dependent homologous recombination repair protein 1 Neighboring gene STE20-like kinase a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein C10orf79; cilia- and flagella-associated protein 43
    Names
    WD repeat domain 96

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      24717880..24743151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_692047.6 → XP_697139.4  cilia- and flagella-associated protein 43

      UniProtKB/TrEMBL
      A0A8N7TBN9
      Related
      ENSDARP00000123525.1, ENSDART00000147713.2
      Conserved Domains (4) summary
      pfam05483
      Location:1072 → 1610
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      COG2319
      Location:283 → 544
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:343 → 389
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:93 → 443
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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