polm polymerase (DNA directed), mu [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: polmprovided by ZNC
Official Full Name: polymerase (DNA directed), muprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-911
See related: Ensembl:ENSDARG00000103470 AllianceGenome:ZFIN:ZDB-GENE-040426-911
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: polmu; zgc:56122
Summary: Predicted to enable DNA-directed DNA polymerase activity. Predicted to be involved in double-strand break repair via nonhomologous end joining. Predicted to act upstream of or within DNA repair. Predicted to be active in nucleus. Is expressed in pleuroperitoneal region and thymus. Orthologous to human POLM (DNA polymerase mu). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (45015225..45029016, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (45168613..45182599, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polmicro expression was detected not only in pro- and mesonephros, the major sites for B-lymphocyte development, but also in ovary and testis and in all tissue preparations to a low extent.
Title: Characterization of terminal deoxynucleotidyl transferase and polymerase mu in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

z35784 (e-PCR), detects polymorphism
- UniSTS:238908

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables DNA-directed DNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via nonhomologous end joining	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed DNA/RNA polymerase mu

Names: DNA polymerase mu

NP_956542.1

EC 2.7.7.7

XP_068079836.1

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200248.1 → NP_956542.1 DNA-directed DNA/RNA polymerase mu

See identical proteins and their annotated locations for NP_956542.1

Status: PROVISIONAL

Source sequence(s)

BC047832

UniProtKB/TrEMBL

Q7ZUU0

Related

ENSDARP00000141586.1, ENSDART00000167878.2

Conserved Domains (2) summary

cd00141
Location:160 → 505

NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

smart00483
Location:158 → 506

POLXc; DNA polymerase X family