micall2b mical-like 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: micall2bprovided by ZNC
Official Full Name: mical-like 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5803
See related: Ensembl:ENSDARG00000017834 AllianceGenome:ZFIN:ZDB-GENE-030131-5803
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: MICAL-2; fi19c04; zgc:55983; zgc:66216; wu:fi19c04
Summary: Predicted to enable F-actin monooxygenase activity and metal ion binding activity. Acts upstream of or within swimming behavior. Is expressed in brain; cloaca; common cardinal vein; heart; and pectoral fin. Orthologous to human MICALL2 (MICAL like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (9460010..9486129, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (8775899..8802018, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data established an important basis for further functional studies of mical family genes in zebrafish, and suggest a possible role for mical genes in cardiovascular development.
Title: Identification and expression analysis of mical family genes in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fi76d02.x1 (e-PCR)
- UniSTS:198006

z8224 (e-PCR), detects polymorphism
- UniSTS:204952

fi19c04.x1 (e-PCR)
- UniSTS:204494

G48003 (e-PCR)
- UniSTS:108768

G40635 (e-PCR)
- UniSTS:25572

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables F-actin monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: protein-methionine sulfoxide oxidase mical2b

Names: MICAL-like 2; molecule interacting with CasL protein 2B; molecule interacting with CasL-like 2b

NP_001299826.1

EC 1.14.13.225

XP_068075613.1

EC 1.14.13.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001312897.1 → NP_001299826.1 protein-methionine sulfoxide oxidase mical2b

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the functional protein.

Source sequence(s)

AL954703, CU914772

UniProtKB/TrEMBL

A0A8M1P2F9, F1QAZ3

Related

ENSDARP00000118632.2, ENSDART00000137821.4

Conserved Domains (3) summary

cd09444
Location:179 → 233

LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins

pfam00307
Location:5 → 102

CH; Calponin homology (CH) domain

pfam12130
Location:609 → 741

DUF3585; Protein of unknown function (DUF3585)

RNA

NR_132439.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' end and uses an alternate internal exon. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL954703, CU914772

Related

ENSDART00000008682.10

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

9460010..9486129 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068219512.1 → XP_068075613.1 protein-methionine sulfoxide oxidase mical2b isoform X1

UniProtKB/TrEMBL

A0A8M1P2F9, F1QAZ3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001199364.1: Suppressed sequence

Description

NM_001199364.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
NM_199833.1: Suppressed sequence

Description

NM_199833.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_200652.1: Suppressed sequence

Description

NM_200652.1: This RefSeq was permanently suppressed because it is an NMD candidate and encodes a protein much shorter than the homolog found in other species.