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    c3a.6 complement C3a, tandem duplicate 6 [ Danio rerio (zebrafish) ]

    Gene ID: 494039, updated on 9-Dec-2024

    Summary

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    Official Symbol
    c3a.6provided by ZNC
    Official Full Name
    complement C3a, tandem duplicate 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-2
    See related
    Ensembl:ENSDARG00000043719 AllianceGenome:ZFIN:ZDB-GENE-041212-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:103710; zgc:153510
    Summary
    Predicted to enable endopeptidase inhibitor activity. Predicted to be located in extracellular space. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and post-vent region. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See c3a.6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (56036644..56080165, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (55360638..55410849, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene paramyosin-like Neighboring gene complement C3a, tandem duplicate 4 Neighboring gene complement C3 Neighboring gene complement C3a, tandem duplicate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dietary β-glucan enhances the contents of complement component 3 and factor B in eggs of zebrafish. Jiang C, et al. Dev Comp Immunol, 2016 Dec. PMID 27375187
    2. Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage. Houseright RA, et al. Sci Rep, 2020 Sep 24. PMID 32973200, Free PMC Article
    3. The evolution and appearance of C3 duplications in fish originate an exclusive teleost c3 gene form with anti-inflammatory activity. Forn-Cuní G, et al. PLoS One, 2014. PMID 24926798, Free PMC Article
    4. Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses. Sehring I, et al. Elife, 2022 Jun 24. PMID 35748539, Free PMC Article
    5. The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish. Liu X, et al. J Dev Biol, 2023 Jun 29. PMID 37489330, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153510

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    complement component c3a, duplicate 6
    Names
    c3.6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008582.4 → NP_001008582.4  complement component c3a, duplicate 6 precursor

      Status: VALIDATED

      Source sequence(s)
      DT079025, LO018626, LO018639
      UniProtKB/TrEMBL
      A0A0R4IMB2, A0A8M1N3I8
      Related
      ENSDARP00000136143.2, ENSDART00000161473.2
      Conserved Domains (8) summary
      cd00017
      Location:669 → 733
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:979 → 1263
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      cd03583
      Location:1493 → 1640
      NTR_complement_C3; NTR/C345C domain, complement C3 subfamily; The NTR domain found in complement C3 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C3 plays a pivotal role in the activation of the complement ...
      pfam00207
      Location:756 → 849
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:130 → 224
      A2M_N; MG2 domain
      pfam07677
      Location:1380 → 1473
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1033 → 1263
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:454 → 590
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      56036644..56080165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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