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    bmp8a bone morphogenetic protein 8a [ Danio rerio (zebrafish) ]

    Gene ID: 561963, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bmp8aprovided by ZNC
    Official Full Name
    bone morphogenetic protein 8aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030912-13
    See related
    Ensembl:ENSDARG00000035677 AllianceGenome:ZFIN:ZDB-GENE-030912-13
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bmp8
    Summary
    Predicted to enable cytokine activity. Acts upstream of or within positive regulation of defense response to virus by host. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in caudal fin; intestine; kidney; liver; and spleen. Orthologous to several human genes including BMP8A (bone morphogenetic protein 8a). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bmp8a in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (35019304..35035857, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (35432184..35448737, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene zgc:91910 Neighboring gene proteasome 20S subunit alpha 2b Neighboring gene microtubule actin crosslinking factor 1a Neighboring gene NADH:ubiquinone oxidoreductase subunit S5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fipronil-induced enantioselective developmental toxicity to zebrafish embryo-larvae involves changes in DNA methylation. Qian Y, et al. Sci Rep, 2017 May 23. PMID 28536466, Free PMC Article
    2. Bmp8a deletion leads to obesity through regulation of lipid metabolism and adipocyte differentiation. Zhong S, et al. Commun Biol, 2023 Aug 8. PMID 37553521, Free PMC Article
    3. Roles of miR-196a and miR-196b in Zebrafish Motor Function. Yuan C, et al. Biomolecules, 2023 Mar 17. PMID 36979489, Free PMC Article
    4. Transcriptional profiling of caudal fin regeneration in zebrafish. Schebesta M, et al. ScientificWorldJournal, 2006 Jun 2. PMID 17205186, Free PMC Article
    5. Bmp8a is an essential positive regulator of antiviral immunity in zebrafish. Zhong S, et al. Commun Biol, 2021 Mar 9. PMID 33750893, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bmp8a deletion leads to obesity through regulation of lipid metabolism and adipocyte differentiation.
      Title: Bmp8a deletion leads to obesity through regulation of lipid metabolism and adipocyte differentiation.
    2. Bmp8a is an essential positive regulator of antiviral immunity in zebrafish.
      Title: Bmp8a is an essential positive regulator of antiviral immunity in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bone morphogenetic protein 8A
    Names
    bone morphogenetic protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044971.1 → NP_001038436.1  bone morphogenetic protein 8A precursor

      Status: PROVISIONAL

      Source sequence(s)
      BX511004
      UniProtKB/TrEMBL
      A0A8N7V0N2, Q1LWW7
      Related
      ENSDARP00000094030.4, ENSDART00000103253.5
      Conserved Domains (2) summary
      smart00204
      Location:332 → 432
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:46 → 284
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      35019304..35035857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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