asip2b agouti signaling protein, nonagouti homolog (mouse) 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: asip2bprovided by ZNC
Official Full Name: agouti signaling protein, nonagouti homolog (mouse) 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-150212-1
See related: Ensembl:ENSDARG00000114760 AllianceGenome:ZFIN:ZDB-GENE-150212-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: A2; asip; agrp2; asip2
Summary: Enables type 1 melanocortin receptor binding activity. Acts upstream of or within negative regulation of cortisol secretion and pigmentation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; gonad; integument; and muscle. Human ortholog(s) of this gene implicated in pigmentation disease. Orthologous to human ASIP (agouti signaling protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (7424040..7431286, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (7552444..7560177, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

By ablation of AgRP1-expressing neurons and knockout of the agrp1 gene, this study shows that AgRP1 stimulates food consumption in the zebrafish larvae. Single-cell sequencing of pineal agrp2-expressing cells revealed molecular resemblance to retinal-pigment epithelium cells, and anatomic analysis shows that these cells secrete peptides, possibly into the cerebrospinal fluid.
Title: Agouti-Related Protein 2 Is a New Player in the Teleost Stress Response System.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables type 1 melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 melanocortin receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adult feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
NOT acts_upstream_of_or_within feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cortisol secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of feeding behavior	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: agouti-signaling protein 2b

Names: agouti related neuropeptide 2; agouti-related peptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.