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    psmb7 proteasome 20S subunit beta 7 [ Danio rerio (zebrafish) ]

    Gene ID: 64278, updated on 9-Dec-2024

    Summary

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    Official Symbol
    psmb7provided by ZNC
    Official Full Name
    proteasome 20S subunit beta 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-001208-4
    See related
    Ensembl:ENSDARG00000037962 AllianceGenome:ZFIN:ZDB-GENE-001208-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    beta2; unp311; C167P9.3; zgc:110090
    Summary
    Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within phosphorylation and proteolysis involved in protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Orthologous to human PSMB7 (proteasome 20S subunit beta 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See psmb7 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (8341790..8352095)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (8249251..8259556)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 6, group A, member 1b Neighboring gene microRNA mir-181a-4 Neighboring gene nuclear receptor subfamily 5, group A, member 1b Neighboring gene NIMA-related kinase 6 Neighboring gene LIM homeobox 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish GAPDH can be used as a reference gene for expression analysis in cross-subfamily cloned embryos. Pei DS, et al. Anal Biochem, 2007 Apr 15. PMID 17239340
    2. Sequencing of amphioxus PSMB5/8 gene and phylogenetic position of agnathan sequences. Takezaki N, et al. Gene, 2002 Jan 9. PMID 11814690
    3. Analysis of a 26-kb region linked to the Mhc in zebrafish: genomic organization of the proteasome component beta/transporter associated with antigen processing-2 gene cluster and identification of five new proteasome beta subunit genes. Murray BW, et al. J Immunol, 1999 Sep 1. PMID 10453006
    4. Induced Torpor as a Countermeasure for Low Dose Radiation Exposure in a Zebrafish Model. Cahill T, et al. Cells, 2021 Apr 14. PMID 33920039, Free PMC Article
    5. Gene duplication, gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family. Kuo MW, et al. Biochem J, 2005 Jul 1. PMID 15725073, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC110090

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables threonine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proteasome subunit beta type-7
    Names
    proteasome (prosome, macropain) subunit, beta type, 7
    proteasome subunit beta 7
    NP_001039029.2
    XP_021324576.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045564.2 → NP_001039029.2  proteasome subunit beta type-7

      See identical proteins and their annotated locations for NP_001039029.2

      Status: PROVISIONAL

      Source sequence(s)
      AL772368
      UniProtKB/TrEMBL
      A0A8N7XJD0, A4QN82, Q7T002
      Related
      ENSDARP00000112303.2, ENSDART00000129749.4
      Conserved Domains (3) summary
      COG0638
      Location:38 → 236
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03763
      Location:44 → 232
      proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
      pfam12465
      Location:236 → 271
      Pr_beta_C; Proteasome beta subunits C terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      8341790..8352095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468901.2 → XP_021324576.1  proteasome subunit beta type-7 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PQK9
      Related
      ENSDARP00000055324.5, ENSDART00000055325.7
      Conserved Domains (2) summary
      cd03763
      Location:44 → 232
      proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
      pfam12465
      Location:237 → 280
      Pr_beta_C; Proteasome beta subunits C terminal
    Nucleotide Protein
    Heading Accession and Version

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