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    ptprk protein tyrosine phosphatase receptor type K [ Danio rerio (zebrafish) ]

    Gene ID: 555348, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ptprkprovided by ZNC
    Official Full Name
    protein tyrosine phosphatase receptor type Kprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9834
    See related
    Ensembl:ENSDARG00000063416 AllianceGenome:ZFIN:ZDB-GENE-030131-9834
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb424; sb:cb424; wu:fa06f08; si:dkey-126h10.3
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in neuron projection development and signal transduction. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in membrane. Is expressed in several structures, including cardiovascular system; digestive system; immature eye; musculature system; and nervous system. Orthologous to human PTPRK (protein tyrosine phosphatase receptor type K). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ptprk in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (1441548..1725064, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (1420725..1863153, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene liver-enriched gene 1, tandem duplicate 1 Neighboring gene thymocyte selection associated Neighboring gene si:dkey-126h10.1 Neighboring gene laminin, alpha 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation. Casar B, et al. Nat Commun, 2018 Sep 5. PMID 30185827, Free PMC Article
    2. Insulin-like growth factor I promotes oocyte maturation through increasing the expression and phosphorylation of epidermal growth factor receptor in the zebrafish ovary. Xie L, et al. Mol Cell Endocrinol, 2016 Jan 5. PMID 26599586
    3. Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Wu W, et al. Sci Rep, 2017 Aug 16. PMID 28814789, Free PMC Article
    4. SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy. See K, et al. Hum Mol Genet, 2014 Apr 1. PMID 24218366
    5. Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. van Eekelen M, et al. PLoS One, 2010 Sep 3. PMID 20838449, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase kappa
    XP_021324239.1
    XP_021324240.1
    XP_021324241.1
    XP_021324242.1
    XP_021324243.1
    XP_021324244.1
    XP_021324245.1
    XP_021324246.1
    XP_021324247.1
    XP_021324248.1
    XP_021324249.1
    XP_021324250.1
    XP_021324252.1
    XP_021324253.1
    XP_021324254.1
    XP_021324255.1
    XP_068071706.1
    XP_068071707.1
    XP_068071708.1
    XP_068071709.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      1441548..1725064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215608.1 → XP_068071709.1  receptor-type tyrosine-protein phosphatase kappa isoform X18

      Related
      ENSDARP00000117401.1, ENSDART00000133369.3

    2. XM_068215607.1 → XP_068071708.1  receptor-type tyrosine-protein phosphatase kappa isoform X16

    3. XM_021468568.2 → XP_021324243.1  receptor-type tyrosine-protein phosphatase kappa isoform X5

      UniProtKB/TrEMBL
      A0A8M9PC25
      Conserved Domains (4) summary
      smart00137
      Location:22 → 183
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:193 → 274
      IG_like; Immunoglobulin like
      cd00047
      Location:932 → 1187
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:483 → 574
      fn3; Fibronectin type III domain

    4. XM_021468579.2 → XP_021324254.1  receptor-type tyrosine-protein phosphatase kappa isoform X19

      UniProtKB/TrEMBL
      A0A8M9PHP9
      Related
      ENSDARP00000086940.5, ENSDART00000092508.7
      Conserved Domains (4) summary
      smart00137
      Location:30 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:201 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:914 → 1142
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:491 → 582
      fn3; Fibronectin type III domain

    5. XM_021468578.2 → XP_021324253.1  receptor-type tyrosine-protein phosphatase kappa isoform X17

      UniProtKB/TrEMBL
      A0A8M9PC34
      Conserved Domains (4) summary
      smart00137
      Location:30 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:201 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:914 → 1148
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:491 → 582
      fn3; Fibronectin type III domain

    6. XM_021468572.2 → XP_021324247.1  receptor-type tyrosine-protein phosphatase kappa isoform X9

      UniProtKB/TrEMBL
      A0A8M9P2U7
      Conserved Domains (4) summary
      smart00137
      Location:30 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:201 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:914 → 1169
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:491 → 582
      fn3; Fibronectin type III domain

    7. XM_021468577.2 → XP_021324252.1  receptor-type tyrosine-protein phosphatase kappa isoform X14

      UniProtKB/TrEMBL
      A0A8M9P2V1
      Conserved Domains (4) summary
      smart00137
      Location:30 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:201 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:926 → 1160
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:491 → 582
      fn3; Fibronectin type III domain

    8. XM_021468575.2 → XP_021324250.1  receptor-type tyrosine-protein phosphatase kappa isoform X13

      UniProtKB/TrEMBL
      A0A8M9PT51
      Conserved Domains (4) summary
      smart00137
      Location:30 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:201 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:930 → 1164
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:491 → 582
      fn3; Fibronectin type III domain

    9. XM_021468569.2 → XP_021324244.1  receptor-type tyrosine-protein phosphatase kappa isoform X6

      UniProtKB/TrEMBL
      A0A8M9PHP0
      Conserved Domains (4) summary
      smart00137
      Location:30 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:201 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:930 → 1185
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:491 → 582
      fn3; Fibronectin type III domain

    10. XM_068215606.1 → XP_068071707.1  receptor-type tyrosine-protein phosphatase kappa isoform X15

    11. XM_021468570.2 → XP_021324245.1  receptor-type tyrosine-protein phosphatase kappa isoform X7

      UniProtKB/TrEMBL
      A0A8M9PT46
      Conserved Domains (4) summary
      smart00137
      Location:30 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:201 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:924 → 1179
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:491 → 582
      fn3; Fibronectin type III domain

    12. XM_021468566.2 → XP_021324241.1  receptor-type tyrosine-protein phosphatase kappa isoform X3

      UniProtKB/TrEMBL
      A0A8M9PPQ9
      Conserved Domains (4) summary
      smart00137
      Location:30 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:201 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:936 → 1191
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:491 → 582
      fn3; Fibronectin type III domain

    13. XM_068215605.1 → XP_068071706.1  receptor-type tyrosine-protein phosphatase kappa isoform X11

    14. XM_021468574.2 → XP_021324249.1  receptor-type tyrosine-protein phosphatase kappa isoform X12

      UniProtKB/TrEMBL
      A0A8M9PHP6
      Conserved Domains (4) summary
      smart00137
      Location:30 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:201 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:940 → 1168
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:491 → 582
      fn3; Fibronectin type III domain

    15. XM_021468573.2 → XP_021324248.1  receptor-type tyrosine-protein phosphatase kappa isoform X10

      UniProtKB/TrEMBL
      A0A8M9PC30
      Conserved Domains (4) summary
      smart00137
      Location:30 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:201 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:940 → 1168
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:491 → 582
      fn3; Fibronectin type III domain

    16. XM_021468571.2 → XP_021324246.1  receptor-type tyrosine-protein phosphatase kappa isoform X8

      UniProtKB/TrEMBL
      A0A8M9PPR4
      Conserved Domains (4) summary
      smart00137
      Location:30 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:201 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:940 → 1174
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:491 → 582
      fn3; Fibronectin type III domain

    17. XM_021468565.2 → XP_021324240.1  receptor-type tyrosine-protein phosphatase kappa isoform X2

      UniProtKB/TrEMBL
      A0A8M9PT41
      Conserved Domains (4) summary
      smart00137
      Location:30 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:201 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:940 → 1192
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:491 → 582
      fn3; Fibronectin type III domain

    18. XM_021468567.2 → XP_021324242.1  receptor-type tyrosine-protein phosphatase kappa isoform X4

      UniProtKB/TrEMBL
      A0A8M9P2U5
      Conserved Domains (4) summary
      smart00137
      Location:30 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:201 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:940 → 1195
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:491 → 582
      fn3; Fibronectin type III domain

    19. XM_021468564.2 → XP_021324239.1  receptor-type tyrosine-protein phosphatase kappa isoform X1

      UniProtKB/TrEMBL
      A0A8M9PHN7
      Conserved Domains (4) summary
      smart00137
      Location:30 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:201 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:940 → 1195
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:491 → 582
      fn3; Fibronectin type III domain

    20. XM_021468580.2 → XP_021324255.1  receptor-type tyrosine-protein phosphatase kappa isoform X20

      UniProtKB/TrEMBL
      A0A8M9PT56
      Conserved Domains (4) summary
      smart00137
      Location:30 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00410
      Location:201 → 282
      IG_like; Immunoglobulin like
      cd00047
      Location:930 → 1158
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00041
      Location:491 → 582
      fn3; Fibronectin type III domain
    Nucleotide Protein Strain
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