apela apelin receptor early endogenous ligand [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: apelaprovided by ZNC
Official Full Name: apelin receptor early endogenous ligandprovided by ZNC
Primary source: ZFIN:ZDB-GENE-090313-116
See related: Ensembl:ENSDARG00000094729 AllianceGenome:ZFIN:ZDB-GENE-090313-116
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ela; tdl; ELABELA; si:ch211-42i9.4
Summary: Enables apelin receptor binding activity and hormone activity. Involved in apelin receptor signaling pathway; gastrulation; and heart development. Acts upstream of with a positive effect on Kupffer's vesicle development. Acts upstream of or within with a positive effect on determination of heart left/right asymmetry and determination of liver left/right asymmetry. Acts upstream of or within blood vessel morphogenesis; chordate embryonic development; and gastrulation. Located in extracellular space. Is expressed in several structures, including Kupffer's vesicle; axis; heart primordium; hypoblast; and mesoderm. Orthologous to human APELA (apelin receptor early endogenous ligand). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (19667947..19673896, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (18975010..18980959, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Apela promotes blood vessel regeneration and remodeling in zebrafish.
Title: Apela promotes blood vessel regeneration and remodeling in zebrafish.
GPR25 is activated by Apela protein.
Title: The orphan G protein-coupled receptor 25 (GPR25) is activated by Apelin and Apela in non-mammalian vertebrates.
These results suggest that Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling and indirectly affects endodermal cell migration via Cxcr4a-signaling.
Title: Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling.
Angioblasts rely on their intrinsic expression of Apelin receptors for their migration to the midline.
Title: The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis.
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Title: Small proteins, big roles: the signaling protein Apela extends the complexity of developmental pathways in the early zebrafish embryo.
These results indicate that Toddler is an activator of APJ/Apelin receptor signaling, promotes gastrulation movements, and might be the first in a series of uncharacterized developmental signals.
Title: Toddler: an embryonic signal that promotes cell movement via Apelin receptors.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables apelin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables apelin receptor binding	IEA Inferred from Electronic Annotation more info
enables apelin receptor binding	TAS Traceable Author Statement more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hormone activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor ligand activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect Kupffer's vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult heart development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within angioblast cell migration from lateral mesoderm to midline	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angioblast cell migration from lateral mesoderm to midline	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apelin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in apelin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within apelin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apelin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in mesendoderm migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell migration involved in mesendoderm migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration involved in mesendoderm migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in coronary vasculature development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_positive_effect determination of heart left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of determination of left/right symmetry	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within_positive_effect determination of liver left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic heart tube development	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endodermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gastrulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	IEA Inferred from Electronic Annotation more info
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesendoderm migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesoderm migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of heart contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of trophoblast cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: apelin receptor early endogenous ligand

Names: Protein Elabela; ende; linc_tmem192; toddler

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.