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    creb1a cAMP responsive element binding protein 1a [ Danio rerio (zebrafish) ]

    Gene ID: 573207, updated on 9-Dec-2024

    Summary

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    Official Symbol
    creb1aprovided by ZNC
    Official Full Name
    cAMP responsive element binding protein 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-750
    See related
    Ensembl:ENSDARG00000053586 AllianceGenome:ZFIN:ZDB-GENE-040426-750
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    creb1; zgc:55598
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cAMP response element binding activity. Acts upstream of or within convergent extension involved in axis elongation; midbrain-hindbrain boundary development; and somitogenesis. Predicted to be located in nucleus. Predicted to be part of ATF4-CREB1 transcription factor complex. Is expressed in nervous system; presumptive neural retina; and proliferative region. Human ortholog(s) of this gene implicated in Parkinson's disease; alcohol dependence; and heroin dependence. Orthologous to human CREB1 (cAMP responsive element binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See creb1a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (33547532..33557843, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (32814964..32825275, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene transfer RNA arginine (anticodon UCU) Neighboring gene CD99 molecule Neighboring gene dehydrogenase/reductase (SDR family) X-linked Neighboring gene charged multivesicular body protein 2Bb Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1Fb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Graphene oxide nanosheets induce DNA damage and activate the base excision repair (BER) signaling pathway both in vitro and in vivo. Lu CJ, et al. Chemosphere, 2017 Oct. PMID 28645083
    2. A novel natural product inspired scaffold with robust neurotrophic, neurogenic and neuroprotective action. Chakravarty S, et al. Sci Rep, 2015 Sep 21. PMID 26388493, Free PMC Article
    3. Wnt2bb Induces Cardiomyocyte Proliferation in Zebrafish Hearts via the jnk1/c-jun/creb1 Pathway. Peng X, et al. Front Cell Dev Biol, 2020. PMID 32523947, Free PMC Article
    4. CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish. Dworkin S, et al. Dev Biol, 2007 Jul 1. PMID 17531969
    5. Common pathways in circadian and cell cycle clocks: light-dependent activation of Fos/AP-1 in zebrafish controls CRY-1a and WEE-1. Hirayama J, et al. Proc Natl Acad Sci U S A, 2005 Jul 19. PMID 16000406, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55598

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within convergent extension involved in axis elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within midbrain-hindbrain boundary development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATF4-CREB1 transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyclic AMP-responsive element-binding protein 1a
    Names
    cAMP responsive element binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200909.1 → NP_957203.1  cyclic AMP-responsive element-binding protein 1a

      See identical proteins and their annotated locations for NP_957203.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044436
      UniProtKB/TrEMBL
      A0A2R8QHW7, B2GNV9, Q803K8
      Related
      ENSDARP00000070114.5, ENSDART00000075632.6
      Conserved Domains (2) summary
      cd14690
      Location:262 → 316
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:91 → 131
      pKID; pKID domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      33547532..33557843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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